Assessing Renal Function After Partial Nephrectomy Using Renal Nuclear Scintigraphy and Estimated Glomerular Filtration Rate

Sankin, Alexander; Sfakianos, John P.; Schiff, Jeffrey; Sjoberg, Daniel D.; Coleman, Jonathan

doi:10.1016/j.urology.2012.04.054

Cited by 28 publications

(19 citation statements)

References 23 publications

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“…Studies reporting on functional outcomes after RAPN have generally used total estimated GFR as a surrogate measure of renal function . This method, although easy and practical, lacks accuracy, as it does not account for the compensation by the contralateral kidney .…”

Section: Introductionmentioning

confidence: 99%

Ipsilateral renal function preservation after robot‐assisted partial nephrectomy (RAPN): an objective analysis using mercapto‐acetyltriglycine (MAG3) renal scan data and volumetric assessment

et al. 2014

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ObjectiveTo objectively assess ipsilateral renal function (IRF) preservation and factors influencing it after robot-assisted partial nephrectomy (RAPN). Patients and MethodsOur database was queried to identify patients who had undergone RAPN from 2007 to 2013 and had complete preand postoperative mercapto-acetyltriglycine (MAG3) renal scan assessment. The estimated glomerular filtration rate (eGFR) for the operated kidney was calculated by multiplying the percentage of contribution from the renal scan by the total eGFR. IRF preservation was defined as a ratio of the postoperative eGFR for the operated kidney to the preoperative eGFR for the operated kidney. The percentage of total eGFR preservation was calculated in the same manner (postoperative eGFR/preoperative eGFR × 100). The amount of healthy rim of renal parenchyma removed was assessed by deducting the volume of tumour from the volume of the PN specimen assessed on pathology. Multivariable linear regression was used for analysis. ResultsIn all, 99 patients were included in the analysis. The overall median (interquartile range) total eGFR preservation and IRF preservation for the operated kidney was 83.83 (75.2-94.1)% and 72 (60.3-81)%, respectively (P < 0.01). On multivariable analysis, volume of healthy rim of renal parenchyma removed, warm ischaemia time (WIT) > 30 min, body mass index (BMI) and operated kidney preoperative eGFR were predictive of IRF preservation. ConclusionsUsing total eGFR tends to overestimate the degree of renal function preservation after RAPN. This is particularly relevant when studying factors affecting functional outcomes after nephron-sparing surgery. IRF may be a more precise assessment method in this setting. Operated kidney baseline renal function, BMI, WIT >30 min, and amount of resected healthy renal parenchyma represent the factors with a significant impact on the IRF preservation. RAPN provides significant preservation of renal function as shown by objective assessment criteria.

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Section: Introductionmentioning

confidence: 99%

Ipsilateral renal function preservation after robot‐assisted partial nephrectomy (RAPN): an objective analysis using mercapto‐acetyltriglycine (MAG3) renal scan data and volumetric assessment

et al. 2014

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“…Therefore, we also evaluated pre-and postoperative changes in eGFR of the operated kidney using the percentage of the operated kidney to both kidneys with renal scintigraphy (eGFR 9 split [%] for the operated kidney). 15 The total operative time, operative blood loss and console time were also measured as perioperative outcomes.…”

Section: Discussionmentioning

confidence: 99%

Prospective study of robotic partial nephrectomy for renal cancer in Japan: Comparison with a historical control undergoing laparoscopic partial nephrectomy

et al. 2018

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“…When using eGFR to assess damage to one kidney, the real damage can be compensated for by increasing the function of the other kidney, thus masking the true damage caused by partial nephrectomy. 12 Therefore, SRF is more sensitive than eGFR in revealing postoperative renal function. 12 All of our patients underwent nuclear scintigraphy scanning for the evaluation of the percentage of diseased kidney to total renal function prior to and regularly after the operation, which is the strength of this study and truly revealed that the renal function of diseased kidneys actually decreased after the operation using this method.…”

Section: Discussionmentioning

confidence: 99%

Impact of warm ischemia time on the change of split renal function after minimally invasive partial nephrectomy in Taiwanese patients

Chung

Huang

et al. 2015

Journal of the Chinese Medical Association

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Assessing Renal Function After Partial Nephrectomy Using Renal Nuclear Scintigraphy and Estimated Glomerular Filtration Rate

Cited by 28 publications

References 23 publications

Ipsilateral renal function preservation after robot‐assisted partial nephrectomy (RAPN): an objective analysis using mercapto‐acetyltriglycine (MAG3) renal scan data and volumetric assessment

Ipsilateral renal function preservation after robot‐assisted partial nephrectomy (RAPN): an objective analysis using mercapto‐acetyltriglycine (MAG3) renal scan data and volumetric assessment

Prospective study of robotic partial nephrectomy for renal cancer in Japan: Comparison with a historical control undergoing laparoscopic partial nephrectomy

Impact of warm ischemia time on the change of split renal function after minimally invasive partial nephrectomy in Taiwanese patients

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