The integration of technology into blended learning has demonstrated remarkable effectiveness as an example of the 21st century learning success. Therefore, it is crucial to prioritize and implement a blended learning approach in the Tahfiz Model Ulul Albab (TMUA) curriculum to generate professional Muslims in various professions who are capable of contributing to holistic individual development. The objective of this study is to assess the relationship between self-regulated learning, mindset, and 21st century skills with blended learning in the TMUA curriculum. A total of 200 students from the Northern Region of Malaysia who are enrolled in the TMUA curriculum at Sekolah Menengah Kebangsaan Agama (SMKA) or National Islamic Secondary School, participated in this study. The relationship between self-regulated learning, mindset, and 21st century skills in blended learning is determined by Pearson correlation analysis using IBM Statistical Package for Social Sciences (SPSS) version 29.0. The findings of the study indicate a strong and significant correlation between 21st century skills and blended learning in the TMUA curriculum among SMKA students. The objective of 21st century learning, which is blended learning in the TMUA curriculum, may be achieved with the support of the school community. It is possible that this will ensure the students' continued success in the future.