The current study proposes a sustainability index (SI) measure based on artificial neural networks (ANN) and globally accepted parameters. Some of the available methods for SI measurement are multi-criteria analysis, external costs, energy analysis, and ecological footprint methods. However, validity remains a concern due to a system's needs, criteria, and requirements. Generally, sustainability is assessed in economic, environmental, and social issues, which varies across regions and countries. Most of the studies accept sub-indices but to a limited extent. Therefore, the proposed study develops an SI evaluation method based on the idea of multi-sustainability incorporating operations, institutions, risks, and climate factors besides economic, environmental, and social issues. All these issues might not be applicable to a single project but may help to develop a complete index when applied. The present study considered different scenarios in building a method to calculate SI using ANN. The results obtained by the ANN model for various input parameters helped to identify the best water conservation strategy. Sensitivity analysis was also performed to determine the uncertainty contribution/significance of the input variables for the water scarcity in the study region. The developed model in the study is tested on a rural water management system.