The study examined the impact of the freight transport sector between cities in Egypt on CO2 emissions, and despite ongoing efforts, there was a significant variation in the use of transportation modes, with a predominant reliance on road transport, while railways and IWT remained underutilized. The importance of the study has returned to evaluating the implications of this variation on CO2 emissions and emphasized the need to innovate sustainable transport solutions in line with Egypt's Vision 2030. The research questions addressed the role of roads, railways, IWT in CO2 emissions and the synergistic effects between them, assuming the existence of relationships between modes of transport and CO2 emissions.To achieve the study's objectives, quantitative and descriptive analyses were conducted using quarterly data from 2013 to 2023. Transportation modes were the independent variable, while CO2 emissions were the dependent variable. The statistical methods included simple and multiple regression analyses using the SPSS program to assess the relationships between transportation modes and emissions. Linear mathematical models were also used to predict future emission levels under transportation scenarios aligned with Egypt's transport sector vision 2030. The analysis results have shown a strong relationship between transportation modes and CO2 emissions, with road transport alone contributing about 92.3% of CO2 emissions. The simultaneous use of all transportation modes has proven to be the most effective approach, resulting in an overall impact of 97.1%. When road and IWT are combined, their cumulative impact reaches 96.9%, while road transport combined with rail transport shows an impact of 92.3%. Forecasts indicate that implementing the proposed scenarios could save approximately 292,462,530 tons of CO2 emissions The study supported the provision of sectorial incentives for managing IWT and railway activities, in addition to enhancing marketing strategies to encourage customers to benefit from these means. It recommended further future research efforts focusing on supply chain interventions to reduce transport emissions.