This study investigates the relationship between school leadership and professional development in the educational setting of Panabo City Division, Philippines. Using a mixed-methods approach, quantitative data were collected through surveys of teachers and school leaders, while qualitative insights were garnered through focus groups and interviews. The data show that school leaders are widely regarded positively, with high mean scores indicating effective participation, supportive behaviors, and clear communication. Similarly, professional development efforts received excellent marks for continual learning, reflective practice, collaborative networking, and creative teaching methods. Statistical research shows a substantial positive association (r = 0.90, p < 0.05) between school leadership and professional development, highlighting the importance of leadership in creating a supportive atmosphere for teacher development. Qualitative findings reveal how supportive leadership behaviors such as resource allocation, collaborative learning communities, and appreciation of teachers' contributions improve professional development outcomes. These findings have practical significance for educational policymakers and school leaders looking to improve leadership practices and maximize professional development programs, which enhances teaching effectiveness.