Assessing the antibiotic potential of essential oils against Haemophilus ducreyi

Lindeman, Zachary; Waggoner, Molly; Batdorff, Audra; Humphreys, Tricia L.

doi:10.1186/1472-6882-14-172

Cited by 7 publications

(6 citation statements)

References 12 publications

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“…The MIC values for the antibiotics against both bacteria were within the range as previously reported in the literature [i.e., 0.06-0.5 μg/mL for doxycycline (Goldstein et al, 2012) and ≤16 μg/mL for tilmicosin (McClary et al, 2011)]. Essential oils are often indicated as alternatives to synthetic antibiotics, due to their antimicrobial activity, as well as low risks of side effects or bacterial resistance (Lindeman et al, 2014). However, such application only becomes true if these compounds are used at high concentrations as feed (Melo et al, 2015) or food additives (Wu et al, 2015), or topically administered (Lindeman et al, 2014).…”

Section: Short Communicationsupporting

confidence: 75%

Short communication: Interaction of the isomers carvacrol and thymol with the antibiotics doxycycline and tilmicosin: In vitro effects against pathogenic bacteria commonly found in the respiratory tract of calves

Kissels

Santos

2017

Journal of Dairy Science

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Bovine respiratory disease is the major problem faced by cattle, specially calves, leading to reduced animal performance and increased mortality, consequently causing important economic losses. Hence, calves must be submitted to antibiotic therapy to counteract this infection usually initiated by the combination of environmental stress factors and viral infection, altering the animal's defense mechanism, and thus allowing lung colonization by the opportunistic bacteria Mannheimia haemolytica and Pasteurella multocida. Essential oils appear to be candidates to replace antibiotics or to act as antibiotic adjuvants due to their antimicrobial properties. In the present study, we aimed to evaluate the 4 essential oil components carvacrol, thymol, trans-anethole, and 1,8 cineole as antibacterial agents or as adjuvants for the antibiotics doxycycline and tilmicosin against M. haemolytica and P. multocida. Bacteria were cultured according to standard protocols, followed by the determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration. A checkerboard assay was applied to detect possible interactions between components, between antibiotics, and between components and antibiotics. Doxycycline at 0.25 and 0.125 μg/mL inhibited the growth of P. multocida and M. haemolytica, respectively, whereas tilmicosin MIC values were 1.0 and 4.0 μg/mL for P. multocida and M. haemolytica, respectively. Carvacrol MIC values were 2.5 and 1.25 mM for P. multocida and M. haemolytica, respectively, whereas thymol MIC values were 1.25 and 0.625 mM for P. multocida and M. haemolytica, respectively. Trans-anethole and 1,8 cineole did not present any antibacterial effect even at 40 mM against the investigated pathogens. All minimum bactericidal concentration values were the same as MIC, except when thymol was tested against M. haemolytica, being twice the MIC data (i.e., 1.25 mM thymol). Based on fractional inhibitory concentration checkerboard assay, no interaction was observed between doxycycline and tilmicosin. Carvacrol and thymol presented an additive effect when one of them was combined with tilmicosin. Additive effect was also observed when doxycycline was combined with thymol. Synergism was observed when carvacrol was combined with doxycycline or with thymol. Although the antibacterial effects of the tested essential oil components were observed at high concentrations for in vitro conditions, the additive and synergic effects of carvacrol and thymol with antibiotics suggest the option to apply them as antibiotic adjuvants.

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Section: Short Communicationsupporting

confidence: 75%

Short communication: Interaction of the isomers carvacrol and thymol with the antibiotics doxycycline and tilmicosin: In vitro effects against pathogenic bacteria commonly found in the respiratory tract of calves

Kissels

Santos

2017

Journal of Dairy Science

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“…The bud EO exhibited MICs of 50, 100 and 400 μg/mL against Haemophilus ducreyi , S. aureus and E. coli , respectively. Leaf EO demonstrated MICs of 250–500 μg/mL against dental pathogens such as Fusobacterium nucleatum, Porphyromonas gingivalis and Streptococcus mitis ( Bersan et al, 2014 ; Lindeman et al, 2014 ; Thielmann et al, 2019 ). Eugenol ( 27 ), a phenolic compound, is the main EO constituent with a concentration ranging from 47.64 to 88.58% ( Chaieb et al, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

et al. 2021

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Background: Antimicrobial resistance represents a serious threat to human health across the globe. The cost of bringing a new antibiotic from discovery to market is high and return on investment is low. Furthermore, the development of new antibiotics has slowed dramatically since the 1950s’ golden age of discovery. Plants produce a variety of bioactive secondary metabolites that could be used to fuel the future discovery pipeline. While many studies have focused on specific aspects of plants and plant natural products with antibacterial properties, a comprehensive review of the antibacterial potential of plants has never before been attempted.Objectives: This systematic review aims to evaluate reports on plants with significant antibacterial activities.Methods: Following the PRISMA model, we searched three electronic databases: Web of Science, PubMed and SciFinder by using specific keywords: “plant,” “antibacterial,” “inhibitory concentration.”Results: We identified a total of 6,083 articles published between 1946 and 2019 and then reviewed 66% of these (4,024) focusing on articles published between 2012 and 2019. A rigorous selection process was implemented using clear inclusion and exclusion criteria, yielding data on 958 plant species derived from 483 scientific articles. Antibacterial activity is found in 51 of 79 vascular plant orders throughout the phylogenetic tree. Most are reported within eudicots, with the bulk of species being asterids. Antibacterial activity is not prominent in monocotyledons. Phylogenetic distribution strongly supports the concept of chemical evolution across plant clades, especially in more derived eudicot families. The Lamiaceae, Fabaceae and Asteraceae were the most represented plant families, while Cinnamomum verum, Rosmarinus vulgaris and Thymus vulgaris were the most studied species. South Africa was the most represented site of plant collection. Crude extraction in methanol was the most represented type of extraction and leaves were the main plant tissue investigated. Finally, Staphylococcus aureus was the most targeted pathogenic bacteria in these studies. We closely examine 70 prominent medicinal plant species from the 15 families most studied in the literature.Conclusion: This review depicts the current state of knowledge regarding antibacterials from plants and provides powerful recommendations for future research directions.

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“…Due to the fact that starting from the 1970s, some strains of H. ducreyi have shown resistance to penicillin and its derivatives and then to sulfonamides, aminoglycosides, tetracyclines, and chloramphenicol it is of particular concern the search of new compounds given the connection between Human Immunodeficiency Virus 1 (HIV-1) and chancroid. The authors showed the antibacterial activity, expressed as MIC and minimum lethal concentrations, of the essential oil obtained from C. verum [ 61 ].…”

Section: Antibacterial Effects Of Cinnamon Essential Oil and Cinnamentioning

confidence: 99%

Antibacterial Effects of Cinnamon: From Farm to Food, Cosmetic and Pharmaceutical Industries

et al. 2015

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Herbs and spices have been used since ancient times, because of their antimicrobial properties increasing the safety and shelf life of food products by acting against foodborne pathogens and spoilage bacteria. Plants have historically been used in traditional medicine as sources of natural antimicrobial substances for the treatment of infectious disease. Therefore, much attention has been paid to medicinal plants as a source of alternative antimicrobial strategies. Moreover, due to the growing demand for preservative-free cosmetics, herbal extracts with antimicrobial activity have recently been used in the cosmetic industry to reduce the risk of allergies connected to the presence of methylparabens. Some species belonging to the genus Cinnamomum, commonly used as spices, contain many antibacterial compounds. This paper reviews the literature published over the last five years regarding the antibacterial effects of cinnamon. In addition, a brief summary of the history, traditional uses, phytochemical constituents, and clinical impact of cinnamon is provided.

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Assessing the antibiotic potential of essential oils against Haemophilus ducreyi

Cited by 7 publications

References 12 publications

Short communication: Interaction of the isomers carvacrol and thymol with the antibiotics doxycycline and tilmicosin: In vitro effects against pathogenic bacteria commonly found in the respiratory tract of calves

Short communication: Interaction of the isomers carvacrol and thymol with the antibiotics doxycycline and tilmicosin: In vitro effects against pathogenic bacteria commonly found in the respiratory tract of calves

A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective

Antibacterial Effects of Cinnamon: From Farm to Food, Cosmetic and Pharmaceutical Industries

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