Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study

Semiç-Jusufagiç, Aida; Belgrave, Danielle; Pickles, Andrew; Telcian, Aurica G.; Bakhsoliani, Eteri; Sykes, Annemarie; Simpson, Angela; Johnston, Sebastian L.; Čustović, Adnan

doi:10.1016/s2213-2600(14)70096-7

Cited by 86 publications

(81 citation statements)

References 30 publications

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“…Consistent with our findings among children living in urban areas, birth cohort studies in Europe and the United States have shown that antibiotic use in early life is associated with asthma or current wheeze, even after adjustment for respiratory infections in early life 15, 24–28 . Unlike our study, however, most of those prior studies did not account for paracetamol use, which has been linked to asthma and allergic rhino-conjunctivitis in young children 29, 30 .…”

Section: Discussionsupporting

confidence: 91%

Antibiotic Use in Early Life, Rural Residence, and Allergic Diseases in Argentinean Children

Han

Forno

Badellino³

et al. 2017

The Journal of Allergy and Clinical Immunology: In Practice

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Background Little is known about differential effects of antibiotic use on allergic diseases in rural versus urban environments. Objective: To examine whether area of residence in the first year of life modifies the relation between antibiotic use in early life and allergic diseases during childhood. Methods Cross-sectional study of allergic diseases in 1,517 children (ages 6–7 years) attending 101 schools in urban and rural areas of San Francisco (Córdoba, Argentina). Current asthma, wheeze, and allergic rhino-conjunctivitis were defined on the basis of responses to a validated questionnaire from the International Study of Asthma and Allergies in Childhood (ISAAC). Multivariate logistic regression was used for the analysis of antibiotic use and allergic diseases. Results After adjustment for paracetamol use, bronchiolitis, and other covariates, antibiotic use in the first year of life was associated with increased odds of current wheeze (odds ratio [OR]=1.8, 95% confidence interval [CI]=1.3–2.6) and allergic rhino-conjunctivitis (OR=1.9, 95% CI=1.3–2.7). After stratification by area of residence, antibiotic use was associated with current wheeze (OR=2.4, 95% CI=1.5–4.0) and allergic rhino-conjunctivitis (OR=2.1, 95% CI=1.3–3.4) among children who lived in an urban area in their first year of life, but not among those who lived in a rural area in their first year of life. Conclusions Early-life antibiotic use is associated with current wheeze and allergic rhino-conjunctivitis in Argentinean children who lived in urban areas during their first year of life. Exposure to a rural environment early in life may protect against the adverse effects of antibiotics on atopic diseases in children.

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Section: Discussionsupporting

confidence: 91%

Antibiotic Use in Early Life, Rural Residence, and Allergic Diseases in Argentinean Children

Han

Forno

Badellino³

et al. 2017

The Journal of Allergy and Clinical Immunology: In Practice

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“…Studies with antibiotic-treated and germ-free mice have demonstrated that lack of innate immune stimulation by commensal bacteria predisposes mice to allergic diseases such as asthma, owing to a general Th2 skewing of the immune system (Huffnagle, 2010; Marsland and Salami, 2015), and also results in more severe disease in chemically-induced models of colitis due to compromised intestinal epithelial barrier integrity (Rakoff-Nahoum et al, 2004). In humans, epidemiological data have indicated that early-life treatment with broad spectrum antibiotics is associated with an increased risk of developing allergic diseases such as asthma (Murk et al, 2011; 2011; Semic-Jusufagic et al, 2014) and may also contribute to the development of inflammatory bowel disease (Ungaro et al, 2014). Little is presently known about the immunological effects of disrupting the healthy intestinal fungal community and whether this could have beneficial or detrimental effects on inflammatory disease development.…”

Section: Introductionmentioning

confidence: 99%

Immunological Consequences of Intestinal Fungal Dysbiosis

Wheeler

Limon

Bar

et al. 2016

Cell Host & Microbe

361

354

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Compared to bacteria, the role of fungi within the intestinal microbiota is poorly understood. In this study we investigated whether the presence of a “healthy” fungal community in the gut is important for modulating immune function. Prolonged oral treatment of mice with antifungal drugs resulted in increased disease severity in acute and chronic models of colitis, and also exacerbated the development of allergic airway disease. Microbiota profiling revealed restructuring of fungal and bacterial communities. Specifically, representation of Candida spp. was reduced, while Aspergillus, Wallemia, and Epicoccum spp. were increased. Oral supplementation with a mixture of three fungi found to expand during antifungal treatment (Aspergillus amstelodami, Epicoccum nigrum, and Wallemia sebi) was sufficient to recapitulate the exacerbating effects of antifungal drugs on allergic airway disease. Taken together these results indicate that disruption of commensal fungal populations can influence local and peripheral immune responses and enhance relevant disease states.

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“…Однако, в последние годы в некоторых исследова-ниях была установлена связь антибактериальной тера-пии в первые месяцы жизни с риском развития у детей в последующем таких заболеваний, как обструктивный бронхит и бронхиальная астма, аллергический ринит, атопический дерматит, ожирение [7][8][9].…”

Section: Background: It Is Assumed That the Severity Of The Multiple unclassified

The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study

Серебрякова¹,

Беляева²,

Волосников³

2017

Pediatr. farmakol.

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Предполагается, что тяжесть синдрома полиорганной недостаточности (СПОН) у детей, перенесших критиче-ские состояния в неонатальном периоде, является фактором высокого риска развития острых респираторных инфекций (ОРИ 0,8 (0,6-0,8) (р=0,003); 4-5 лет -0,6 (0,6-0,7) и 0,4 (0,4-0,5) (р=0,001); 5-6 лет -0,5 (0,3-0,5) и 0,3 (0,2-0,3) (р=0,001); 6-7 лет -0,3 (0,3-0,3) и 0,1 (0,1-0,3) (р=0,025

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Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study

Abstract: Moulton Charitable Foundation and Medical Research Council.

Cited by 86 publications

References 30 publications

Antibiotic Use in Early Life, Rural Residence, and Allergic Diseases in Argentinean Children

Antibiotic Use in Early Life, Rural Residence, and Allergic Diseases in Argentinean Children

Immunological Consequences of Intestinal Fungal Dysbiosis

The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study

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