Assessing the Benefits of Research

Abstract

Writing a book requires a substantial time commitment, and I would like to thank my family for their patience. It also requires resources, and I would like to thank Stony Brook University and the Department of Technology and Society in particular for its support. Thanks also goes out to David Tonjes for his helpful advice and Scott Ferson for his gracious support and instructive discussions regarding the nature of risk and the measurement of uncertainty. I must also express my deep gratitude to the late David Ferguson, instrumental in my academic career, who imparted kindness and wisdom in equal measure. Finally, I would like to thank Sheldon Reaven for our numerous conversations on the philosophy of science, science policy, and opera. The value of his insightful comments has been exceeded only by the value of his friendship. This book has also benefitted from the insightful peer review comments provided by Professor Frederic Emmanuel Bouder. Case Study: H5N1 Influenza Research Debate Media coverage of the latest scientific discoveries and technological innovations is usually enthusiastic. Long-standing questions are answered, productivity is increased, health is improved, and our standard of living is raised-all due to modern science and human ingenuity. However, sometimes the results of research can also inspire public fear and outrage. Let us consider a recent example. In September 2011, Dutch virologist Ron Fouchier announced at a conference in Malta that his research team had recently engineered a version of the H5N1 1 avian influenza virus that was highly transmissible between mammals. Shortly thereafter, virologist Yoshihiro Kawaoka of the University of Wisconsin presented results from a similar study. The subsequent media coverage scared the general public and set off demands for a review of how science research is assessed, funded, and managed. Why would these studies be so scary? The reason centers on the lethal potential of influenza and the H5N1 virus in particular. An influenza pandemic typically occurs when a flu virus substantially different from circulating viruses mutates to become easily transmissible between humans. The combination of 1 The formal naming convention for influenza viruses includes the antigenic type (A, B, or C); the originating host (e.g., swine); the geographical origin; year of identification; strain number; or for type A viruses, the specific subtypes of two surface proteins, hemagglutinin (H) and neuraminidase (N) (e.g., H5N1) (Assaad et al. 1980). Given the complexity of formal names, popular shorthand names, such as Spanish flu, Swine flu, and H1N1 can potentially be referring to the same influenza virus. The World Health Organization has been working to improve shorthand names to make them less stigmatizing and more informative.