2010
DOI: 10.1016/j.ejmech.2010.01.048
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Assessing the chemical diversity of an hsp90 database

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Cited by 21 publications
(3 citation statements)
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“…This concept is closely related to the notion of chemical diversity. The diversity of a chemical library is a quantitative description of how different these compounds are from each other, with similar compounds and similar biological activities falling in the same chemical space region [73] . For this, we used k -means clustering via PCA, a method to compute the position of every compound in a two-dimensional coordinate system based on a set of computed properties.…”
Section: Discussionmentioning
confidence: 99%
“…This concept is closely related to the notion of chemical diversity. The diversity of a chemical library is a quantitative description of how different these compounds are from each other, with similar compounds and similar biological activities falling in the same chemical space region [73] . For this, we used k -means clustering via PCA, a method to compute the position of every compound in a two-dimensional coordinate system based on a set of computed properties.…”
Section: Discussionmentioning
confidence: 99%
“…Each monomer consists of three structurally conserved domains (Figure 2) 40 . The HSP90 protein consists of three domains: the N-terminal domain (NTD), which binds to nucleotides (ATP) and inhibitors such as radicicol, geldanamycin, and its derivatives; the middle domain (MD), which binds to client proteins and co-chaperones; and the C-terminal domain (CTD), which facilitates the formation of HSP90 dimers 41,42 . HSP90 has been a prominent focus for therapeutic intervention in various disorders, such as cancer, Parkinson's disease, and Alzheimer's disease.…”
Section: Heat Shock Protein 90mentioning
confidence: 99%
“…Within the last 15 years, small molecule Hsp90 inhibitors have provided a new class of anti-neoplastic agents that are mechanistically distinct from other chemotherapeutics. 1015 Although Hsp90 inhibition represents a promising approach toward cancer; Hsp90 inhibitors also exhibit detrimental properties at present.…”
mentioning
confidence: 99%