Assessing the Correlation Between<sup>68</sup>Ga-PSMA-11 Renal PET Parameters and Renal Function Tests

Schierz, Jan-Henning; Sarıkaya, İsmet; Albatineh, Ahmed N.; Sarıkaya, Ali

doi:10.2967/jnmt.121.262462

Cited by 6 publications

(9 citation statements)

References 30 publications

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“…Schierz and colleagues found that renal segmentation volume, as well as the renal SUV mean ‐to‐blood pool SUV mean ratio, and the renal SUV mean ‐to‐liver SUV mean ratio, correlated with MDRD eGFR in a study of 25 patients undergoing [ 68 Ga]Ga‐PSMA‐11 PET (Schierz et al, 2021 ). To the best of our knowledge, the present study is the first to demonstrate a correlation between [ 18 F]PSMA‐1007 PET parameters and eGFR, and it included a considerably larger study population.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study on 25 patients found correlations between [ 68 Ga]Ga‐PSMA‐11 PET parameters and estimated GFR (eGFR), with two patients excluded due to high activity in renal calyces (Schierz et al, 2021 ). [ 18 F]PSMA‐1007 has significantly lower urinary excretion than [ 68 Ga]Ga‐PSMA‐11 (Afshar‐Oromieh et al, 2016 ; Giesel et al, 2017 ), making renal uptake easier to distinguish, and thus, potentially making it more suitable for quantification and imaging and of renal cortical function.…”

Section: Introductionmentioning

confidence: 99%

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[¹⁸F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

Valind

Jögi

Minarik

et al. 2022

Clin Physio Funct Imaging

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Background Scintigraphy with technetium‐99m‐labelled dimercaptosuccinic acid ([99mTc]Tc‐DMSA) is widely used for renal cortical imaging. Uptake of [99mTc]Tc‐DMSA has been shown to correlate with glomerular filtration rate (GFR). Prostate‐specific membrane antigen (PSMA) radiopharmaceuticals used for positron emission tomography (PET) show high renal uptake and are being investigated for renal imaging. [68Ga]Ga‐PSMA‐11 PET parameters have been shown to correlate with estimated GFR (eGFR). The aim of this study was to investigate the relationship between renal [18F]PSMA‐1007 uptake and eGFR. Methods Hundred and eighty‐five patients underwent PET imaging at 1 and 2 h after injection of 4.0 ± 0.2 MBq [18F]PSMA‐1007. Serum creatinine levels were measured and GFR estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) and Modification of Diet in Renal Disease (MDRD) equations. Fifteen patients were excluded due to missing or incorrect data. Thus, data from 170 patients were analyzed. Kidneys were segmented in the PET images using a convolutional neural network with manual correction. For each kidney, mean standardized uptake value (SUVmean) and segmentation volume in millilitres were measured. Linear regression analyses were performed with eGFR as the outcome variable. Results Variation in the eGFR values was explained to a significant degree by SUVmean and renal segmentation volume in both the 1 and 2 h images. This correlation was stronger for CKD‐EPI eGFR (1 h R2 = 0.64; 2 h R2 = 0.64) than for MDRD eGFR (1 h R2 = 0.47; 2 h R2 = 0.45). Conclusion Renal [18F]PSMA‐1007 uptake parameters correlate with eGFR and are indicative of renal cortical function.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

[¹⁸F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

Valind

Jögi

Minarik

et al. 2022

Clin Physio Funct Imaging

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“…PSMA is physiologically overexpressed in the proximal tubular cells of the kidneys and 68 Ga-PSMA is excreted via the renal system [ 24 ]. Several studies have shown the utility of PSMA in the imaging of renal function [ 25 , 26 , 27 , 28 ]; therefore, we hypothesised that 68 Ga-PSMA PET/CT imaging could be used as a surrogate for the determination of PSMA-PETderived split renal function (SRF) at baseline, to assess kidney function and detect changes during follow-up, and to rule out obstruction induced by tumour or renal dysfunction caused by PSMA-targeted radioligand treatment.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of 68Ga-PSMA PET/CT-Based Split Renal Function with 99mTc-MAG3 Renography in Patients with Metastatic Castration-Resistant Prostate Carcinoma Treated with 177Lu-PSMA

Gabela,

Mkhize,

Hadebe

et al. 2024

Diagnostics

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Background: Physiological PSMA expression in the cells of the proximal renal tubules and consecutive radiopharmaceutical binding and retention could potentially lead to radioligand-therapy-induced nephrotoxicity. Thus, patients with metastatic castration-resistant prostate cancer undergo 99mTc-Mercaptoacetyltriglycine (MAG3) renal scintigraphy to assess kidney function and to exclude renal obstruction as part of their workup for PSMA-targeted radioligand therapy (RLT). 99mTc-MAG-3 renal scintigraphy often requires an additional visit to the nuclear medicine department and patients spend 30–90 min in the department, which is inconvenient and takes up camera time. In addition, the patients are subjected to a baseline 68Ga-PSMA PET/CT to assess for PSMA-positive disease prior to targeted radioligand therapy. The aim of this retrospective cross-sectional study was to compare 99mTc-MAG-3-based split renal function (SRF) with 68Ga-PSMA-derived SRF. Methods: This retrospective cross-sectional study included 28 patients with histologically proven metastatic castration-resistant prostate cancer (mCRPC) who received 177Lu-PSMA617. A comparison between the split renal function using 68Ga-PSMA PET/CT and the 99mTc-MAG-3-derived split renal function was carried out in 56 kidneys (n = 56). The SRF on 68Ga-PSMA was calculated using the volume and the average standard uptake value (SUVmean) within each VOI calculated as previously described by Roser et al.: SRF = (VOLUMEright) ∗ SUVmeanright/(VOLUMEright ∗ SUVmeanright + VOLUMEleft ∗ SUVmeanleft). Paired tests and correlation coefficients were used to compare 68Ga-PSMA and 99mTc-MAG-3. A visual comparison of kidney morphology on both studies was also performed. Results: The median SRF of the right kidney was 49.9% (range: 3–91%) using 68Ga-PSMA PET/CT and 50.5% (range: 0–94%) with 99mTc-MAG3 scintigraphy. Notably, there was a strong correlation between SRF measurements obtained from PSMA and 99mTcMAG3, with a Pearson correlation coefficient of 0.957 (p < 0.001). Both 99mTc-MAG3 and 68Ga-PSMA PET/CT studies identified morphological renal abnormalities; there were nine hydronephrotic kidneys, four shrunken kidneys and one obstructed kidney, and there was a strong positive correlation between 68Ga-PSMA kidney morphology and 99mTcMAG3 renal scintigraphy kidney morphology, with a correlation coefficient of 0.93. Conclusions: PSMA-derived split function demonstrated a high correlation with renal function assessed on diuretic 99mTc-MAG3 renograms. PET-derived split renal function may, therefore, be considered an alternative to diuretic renogram-based split function. Furthermore, both 99mTc-MAG3 and 68Ga-PSMA PET/CT studies identified morphological renal abnormalities such as hydronephrosis, shrunken and obstructed kidneys. This correlation underscores the potential utility of 68Ga-PSMA imaging as a valuable tool for assessing kidney morphology as an alternative to renogram split function in clinical practice.

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“…[ 68 Ga]Ga-PSMA-11 PET has been compared to technetium-99m labeled dimercaptosuccinic acid (DMSA) scan in two adult patients with pyelonephritis [ 6 , 7 ]. A recent study has shown correlation between renal uptake of [ 68 Ga]Ga-PSMA-11 and renal function as measured with glomerular filtration rate (GFR) [ 8 ]. A comparison of split renal function using technetium-99m labeled mercaptotriglycene ([ 99m Tc]Tc-MAG3) renography and [ 68 Ga]Ga-PSMA-11 PET has shown reasonable agreement between the modalities [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Dose-reduced [18F]PSMA-1007 PET is feasible for functional imaging of the renal cortex

et al. 2021

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Background In Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy with technetium-99m labeled dimercaptosuccinic acid (DMSA). Using [68Ga]Ga-PSMA-11 PET for renal imaging has been suggested, but using [18F]PSMA-1007 has not been explored. The aims of this study were to establish the optimal time point for renal imaging after [18F]PSMA-1007 injection, to investigate the reproducibility of split renal uptake measurements, and to determine the margin for reduction in administered activity. Methods Twelve adult male patients with prostate cancer underwent [18F]PSMA-1007 PET-CT at 8 time points up to 5.5 h post-injection (p.i.). List-mode data were binned to durations of 10 to 120 s per bed position (bp). Left renal percentage of total renal uptake (LRU%) was measured, and the difference between highest and lowest measurement per patient (“delta max”) was calculated. Images acquired at 1 h, 2 h, and 5.5 h p.i. with durations of 10 to 120 s/bp were rated regarding image quality. Results Imaging at 2 h p.i. with 60 s/bp yielded acceptable quality in all cases. Increasing acquisition time to 15 min for a single bp would allow reducing administered activity to 0.27 MBq/kg, resulting in an effective dose of 0.4 mSv for a 1-year old child weighing 10 kg. The median delta max of LRU% measurements was 2.7% (range 1.8–7.3%). Conclusions Renal [18F]PSMA-1007 PET-CT is feasible, with imaging 2 h p.i., acceptable split renal uptake variability, and effective dose and acquisition time comparable to those of [99mTc]Tc-DMSA scintigraphy.

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Assessing the Correlation Between⁶⁸Ga-PSMA-11 Renal PET Parameters and Renal Function Tests

Cited by 6 publications

References 30 publications

[¹⁸F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

[¹⁸F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

A Comparison of 68Ga-PSMA PET/CT-Based Split Renal Function with 99mTc-MAG3 Renography in Patients with Metastatic Castration-Resistant Prostate Carcinoma Treated with 177Lu-PSMA

Dose-reduced [18F]PSMA-1007 PET is feasible for functional imaging of the renal cortex

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Assessing the Correlation Between68Ga-PSMA-11 Renal PET Parameters and Renal Function Tests

Cited by 6 publications

References 30 publications

[18F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

[18F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

A Comparison of 68Ga-PSMA PET/CT-Based Split Renal Function with 99mTc-MAG3 Renography in Patients with Metastatic Castration-Resistant Prostate Carcinoma Treated with 177Lu-PSMA

Dose-reduced [18F]PSMA-1007 PET is feasible for functional imaging of the renal cortex

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Assessing the Correlation Between⁶⁸Ga-PSMA-11 Renal PET Parameters and Renal Function Tests

[¹⁸F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate

[¹⁸F]PSMA‐1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate