Assessing the cytotoxic effect of hexabromocyclododecane (HBCD) on liver tissue cultures from fathead minnow (Pimephales promelas)

Bertucci, Juan Ignacio; Bandaralage, Susari Malala Irugal; Hecker, Markus

doi:10.1016/j.aquatox.2020.105523

Cited by 9 publications

(5 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The environment deteriorates more and more with the increasing use of energy. Other studies have also found similar results (Bertucci et al, 2020;Halliru et al, 2020) found that increased energy use increases pollution.…”

Section: P-ardl Model Resultssupporting

confidence: 65%

Does Degree of Stringency Matter? Revisiting the Pollution Haven Hypothesis in BRICS Countries

Wen

Haseeb

Safdar

et al. 2022

Front. Environ. Sci.

View full text Add to dashboard Cite

This study aims to demonstrate the validity of the Pollution Haven Hypothesis (PHH) for BRICS nations by revealing the empirical relationship between foreign direct investment (FDI), air pollution, and environmental regulations. At the same time, the study objectives are based on the BRICS′ COP26 goals focused on mobilizing climate finance annually. The SDGs agenda for 2030 seeks to implement effective climate change planning and management. However, the study uses the panel data of BRICS countries from 2000 to 2020. This study has used the PMG/PARDL model to empirically test the existence of PHH in BRICS countries. Therefore, the empirical estimates indicate that an increase in FDI increases environmental degradation. Consequently, the findings confirm the existence of PHH in BRICS. This study demonstrates that at low levels of stringency, the likelihood of pollution-intensive FDIs increases with a decrease in severity. Even though strict regulations may lead to higher pollution-intensive foreign direct investment (FDI), this is not always the case at lower levels of law. This implies that the same pollution activity may be economically and socially unsuitable for developed environments but desirable for less advanced environments. These distinctions are the foundation for the emergence of pollution havens. Therefore, environmental policy laxity must be formed to induce FDI flow into the BRICS countries, further implying SDG’s accomplishment. Furthermore, additional stringent regulations might very well result in FDIs with a more significant environmental impact. This suggests that pollution havens are only possible if environmental rules are lax or inconsequential.

show abstract

Section: P-ardl Model Resultssupporting

confidence: 65%

Does Degree of Stringency Matter? Revisiting the Pollution Haven Hypothesis in BRICS Countries

Wen

Haseeb

Safdar

et al. 2022

Front. Environ. Sci.

View full text Add to dashboard Cite

show abstract

“…Figure 1 shows the concentrations of α-, β-, and γ-HBCD in various tissues from N. albiflora following exposures of 3 and 6 days. These variations underscore the differential impacts of pollution sources and exposure durations on the accumulation of these compounds, as suggested by Bertucci et al (2020). The HBCDs accumulated with time in all tissues (except the βand γ-HBCD-treated group in gallbladder), though the rates were inconsistent.…”

Section: Distribution Characteristics and Selective Accumulation Of H...mentioning

confidence: 77%

The distribution and metabolism of hexabromocyclododecane isomers varies in the tissues of Nibea albiflora

Song,

Sun,

Cheng

et al. 2023

Front. Environ. Sci.

View full text Add to dashboard Cite

Hexabromocyclododecanes (HBCDs), as brominated flame retardants, have increasingly drawn concern due to their detection in various marine organisms in recent years. The present test investigated the selective accumulation, depuration, and bioisomerization of HBCDs in different tissues and organs of Nibea albiflora, as well as the genetic metabolic behavior of HBCDs between parents and offspring. In a semi-static water environment, N. albiflora were exposed to individual HBCD diastereoisomers (α-HBCD, β-HBCD, or γ-HBCD) at a concentration of 0.4 μg/L for bioaccumulation, followed by clean food for depuration. During the exposure period, the highest concentrations of these HBCDs were observed in the intestine and gill of N. albiflora. α-HBCD was detected in all exposure groups, suggesting that both β-HBCD and γ-HBCD could be bioisomerized to α-HBCD in N. albiflora. In addition, there was no bioisomerization of α-HBCD to either β-HBCD or γ-HBCD, and there was no bioisomerization between β-HBCD and γ-HBCD. The half-lives (t1/2) were variable among different diastereoisomers, following an order of α-HBCD > γ-HBCD > β-HBCD. The most rapid depuration rate of HBCDs was discovered in the liver while muscle showed the least. Additionally, prior to spawning, the parent fish were exposed to contaminated feed (silkworms sprayed with 200 μL of a 30 μg/mL HBCD solution) for 6 days. By comparing the HBCDs concentrations in the maternal gonad, fertilized eggs, hatching eggs, larvae, and juveniles, it was determined that the maternal transfer coefficients for HBCDs were approximately 1, indicating dynamic equilibrium of HBCDs throughout the process from maternal tissue to progeny development. Differences in HBCDs pattern between organs observed in the experiment support a proposal of an organ-specific diastereomer accumulation.

show abstract

“…Hormesis is a biphasic or triphasic response characterized by a stimulatory or beneficial effect at low concentrations and an inhibitory or toxic effect at high concentrations (Mattson, 2008). Studies with HBCD observing apical, biological, and molecular endpoints have described such responses (Bertucci et al, 2020; Wang et al, 2016; Wu et al, 2013). Wu et al (2013) observed higher hatching rates with water‐borne exposure to HBCD and noted a significant increase in hatching rate at the low concentration (2 nM) compared with the control.…”

Section: Discussionmentioning

confidence: 99%

Maternal Transfer and Apical and Physiological Effects of Dietary Hexabromocyclododecane Exposure in Parental Fathead Minnows (Pimephales promelas)

Bandaralage

Bertucci

Park

et al. 2022

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Hexabromocyclododecane (HBCD) is a persistent organic pollutant that has been characterized as an endocrine disruptor, undergoes maternal transfer, and hinders development and growth in oviparous organisms. The present study examined the apical effects of dietary HBCD (11.5, 36.4, 106 mg/kg, wet wt) on adult fathead minnow exposed for 49 days and the subsequent accumulation and maternal transfer kinetics in adult tissue and eggs, respectively. Exposed adults displayed a significant increase in egg production in the medium treatment group, but no other significant effects were noted. Maternal transfer of dietary HBCD had a similar egg-to-muscle ratios (EMR) in the low and medium treatment groups (1.65 and 1.27 [wet wt], respectively). However, the high treatment group deviated from other treatments with an EMR of 4.2 (wet wt), potentially due to differences in total lipid content in food and/or reaching diffusion/lipid saturation limits in adult tissue, resulting in lower accumulation in the adult muscle tissue. A positive correlation was observed between egg HBCD concentration and time of exposure, which indicates that maternal transfer of HBCD is of concern in fish, and further studies should be conducted to fully elucidate the potential adverse effects that may be observed in the early life stage of oviparous organisms.

show abstract

Assessing the cytotoxic effect of hexabromocyclododecane (HBCD) on liver tissue cultures from fathead minnow (Pimephales promelas)

Cited by 9 publications

References 50 publications

Does Degree of Stringency Matter? Revisiting the Pollution Haven Hypothesis in BRICS Countries

Does Degree of Stringency Matter? Revisiting the Pollution Haven Hypothesis in BRICS Countries

The distribution and metabolism of hexabromocyclododecane isomers varies in the tissues of Nibea albiflora

Maternal Transfer and Apical and Physiological Effects of Dietary Hexabromocyclododecane Exposure in Parental Fathead Minnows (Pimephales promelas)

Contact Info

Product

Resources

About