Assessing the effect of fine particulate matter on adverse birth outcomes in Huai River Basin, Henan, China, 2013–2018

Zhang, Huanhuan; Zhang, Xiaoan; Zhang, Han; Luo, Hongyan; Yang, Feng; Wang, Jingzhe; Huang, Cunrui; Yu, Zengli

doi:10.1016/j.envpol.2022.119357

Cited by 14 publications

(3 citation statements)

References 72 publications

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“…We observed that the adjusted estimates for PM 2.5 , PM 10, and NO 2 exposures with LBW were in the expected direction of adverse effects, as in previous studies 46 and in line with the main analysis. The results on PTB may be chance findings due to small numbers of PTB events, as air pollution tends to be related to a higher risk of PTB rather than the opposite.…”

Section: Discussionsupporting

confidence: 91%

Pregnancy outcomes as related to in utero exposure to air pollution and greenness: The Life-GAP Project

Sinsamala,

Johannessen,

Bertelsen

et al. 2024

Environmental Epidemiology

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Background: Lower birth weight and preterm birth may increase the risk of adverse health outcomes later in life. We examined whether maternal exposure to air pollution and greenness during pregnancy is associated with offspring birth weight and preterm birth. Methods: We analyzed data on 4286 singleton births from 2358 mothers from Respiratory Health in Northern Europe, a prospective questionnaire-based cohort study (1990–2010). Mixed-effects regression models with random intercepts for mothers and centers were used to estimate the association of exposures to particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), ozone (O3), black carbon (BC), and greenness (Normalized Difference Vegetation Index in 300m-buffers [NDVI300m]) with birth outcomes, adjusting for potential confounders. Results: Median (interquartile range [IQR]) exposures to PM2.5, PM10, NO2, O3, BC, and NDVI300m during pregnancy were 8.4(5.0) µg/m3, 14.4(8.3) µg/m3, 14.0(11.0) µg/m3, 54.7(10.2) µg/m3, 0.47(0.41) µg/m3, and 0.31(0.20), respectively. IQR increases in air pollution exposures during pregnancy were associated with decreased birth weight and the strongest association was seen for PM2.5 (−49g; 95% confidence interval [CI] = −83, −16). However, O3 showed an opposite association. IQR increase in NDVI300m was associated with an increase in birth weight of 25 g (95% CI = 7, 44). Preterm birth was not associated with the exposures. Conclusion: Increased greenness and decreased air pollution may contribute to healthier pregnancies and improve overall health in the next generation. This emphasizes the need to adopt policies that target the reduction of air pollution emissions and exposure of the population.

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Section: Discussionsupporting

confidence: 91%

Pregnancy outcomes as related to in utero exposure to air pollution and greenness: The Life-GAP Project

Sinsamala,

Johannessen,

Bertelsen

et al. 2024

Environmental Epidemiology

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“…The sources of particulate matter are diverse, and include industrial emissions, vehicles, and wild res, with 25% coming from burning fuel. However, most activities were carried out indoors because of decreased mobility owing to pregnancy or the increased popularity of working from home; thus, the indoor sources of particulate matter should be considered when analysing the effect of particulate matter in pregnancy (2,9).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies showed that exposure to particulate matter is associated with adverse pregnancy outcomes and metabolic syndrome (5)(6)(7)(8). However, the degree of harmful exposure to particulate matter is still inconclusive (9). Furthermore, animal studies suggest that particulate matter induces oxidative stress and systemic in ammation, which can cause metabolic dysfunction, including elevated blood pressure and altered lipid and glucose metabolism (10).…”

Section: Introductionmentioning

confidence: 99%

Effects of PM 2.5 exposure on metabolic dysfunction during pregnancy via personalized measurement of pollutant concentration in South Korea: A multicenter prospective cohort, air pollution on pregnancy outcome (APPO) study

Jeong

Park

Kwon

et al. 2022

Preprint

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Background Ambient particulate matter (PM) is a trigger factor for metabolic dysfunction. This study aimed to evaluate the associations between PM exposure and metabolic dysfunction in pregnancy. Methods This prospective, multicentre, observational, cohort study was conducted from January 2021 to June 2022. A total of 333 women with singleton pregnancies were recruited. For individual measurement of PM2.5 levels, an AirguardK® was installed inside the participants’ houses. Time-activity logs were recorded to predict each participant’s personal exposure to PM2.5. The participants were divided into groups according to the concentration of PM2.5 calculated by a time-weighted average model. We used the Student t-test and chi-squared test (or Fisher’s exact test) to evaluate changes in metabolic compound levels, blood pressure (BP), glucose intolerance, and lipid profiles, including serum triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratios. Logistic and linear regression models were used to analyse the association between PM2.5 exposure and metabolic dysfunction, using odds ratios (ORs) and 95% confidence intervals (CIs). Results PM2.5 exposure during pregnancy worsened metabolic dysfunction. Third trimester BP was elevated in those participants exposed to higher levels of PM2.5 (p <0.05). The incidence of gestational diabetes mellitus (GDM) was constantly higher in those exposed to more PM2.5, regardless of the PM2.5 cut-off level (PM2.5 ≥10 µg/m3, 7.91 % vs. 16.09 %, p <0.05; PM2.5 ≥25 µg/m3, 7.91 % vs. 26.67 %, p <0.05). The proportion with a TG/HDL-C ratio ≥3.0 was significantly higher when PM2.5 was ≥10 µg/m3 (75.3 % vs. 83.0 %, p <0.05). Triglyceride levels were significantly higher in the PM2.5 ≥25 µg/m3 group (p=0.0171). We found an increased risk of elevated BP (adjusted OR [aOR]: 2.228, 95% CI: 1.115–4.449) and GDM (aOR 2.263, 95% CI 1.106–5.039) in the third trimester after adjusting for confounders. Conclusion Exposure to PM2.5 worsens metabolic dysfunction in pregnancy. Further studies are required to investigate the mechanisms by which ambient PM affects metabolic dysfunction in pregnancy.

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Identifying the critical windows of temperature extremes exposure and congenital heart diseases

Zhang,

Feng,

Huang

et al. 2024

Int J Biometeorol

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Assessing the effect of fine particulate matter on adverse birth outcomes in Huai River Basin, Henan, China, 2013–2018

Cited by 14 publications

References 72 publications

Pregnancy outcomes as related to in utero exposure to air pollution and greenness: The Life-GAP Project

Pregnancy outcomes as related to in utero exposure to air pollution and greenness: The Life-GAP Project

Effects of PM 2.5 exposure on metabolic dysfunction during pregnancy via personalized measurement of pollutant concentration in South Korea: A multicenter prospective cohort, air pollution on pregnancy outcome (APPO) study

Identifying the critical windows of temperature extremes exposure and congenital heart diseases

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