Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women

Abstract

Migraine is a widespread incapacitating neurologic disorder with debilitating headaches which are usually throbbing due to inefficacy and several side effects, complementary therapies recommended as possible alternatives. The current randomized controlled trial was carried out to evaluate the effect of zinc gluconate supplementation on migraine-related symptoms, serum level of high sensitivity C-reactive protein (hs-CRP) and lipid profile in migraineurs. Present study was designed as randomized double-blind, placebo-controlled trial. Sixty women with migraine (mean age of 35.44 ± 7.42 years ) were randomly allocated to obtain 15 mg per day of zinc gluconate or placebo for 12 weeks. Frequency, periods of headaches and severity of migraine based on numerical rating scale questionnaire and migraine disability assessment (MIDAS) test were checked. Fasting serum level of lipid profile and hs-CRP were assessed at the beginning and the end of trial. Zinc gluconate supplementation significantly reduced the frequency (p = 0.001), periods of migraine attacks (p < 0.001) and severity of migraine and MIDAS (p < 0.001) compared with control group. The serum level of low-density lipoprotein (p < 0.001), total cholesterol (p < 0.001) and hs-CRP (p < 0.001) decreased following zinc supplementation, but no significant differences in serum level of triglycerides (p = 0.1) and high-density lipoprotein (p = 0.3) was observed. However, after adjustment for baseline values using analysis of covariance test, none of lipid profile components and hs-CRP showed a significant difference. Zinc supplementation has beneficial effect on the migraine related complications like its severity, frequency. Trial Registration Iranian Registry of Clinical Trials Identifier: IRCT20191014045100N1

Dietary zinc intake and migraine in adults: a cross‐sectional analysis of the National Health and Nutrition Examination Survey 1999–2004

“…42 Oral zinc supplementation reduced migraine severity and frequency in previous randomized controlled trials. 12,13 However, few studies assessed the effects of dietary zinc intake on migraine in the US population. The present study demonstrated an inverse relationship between dietary zinc intake and migraine.…”

“…Dhillon et al treated individuals living with migraine disease with 75 mg of zinc sulfate and vitamins for 6 weeks with a good response 42 . Oral zinc supplementation reduced migraine severity and frequency in previous randomized controlled trials 12,13 . However, few studies assessed the effects of dietary zinc intake on migraine in the US population.…”

“…As a cofactor for antioxidant enzymes, it plays a crucial role in neuronal signaling 10 . Previous studies have reported lower serum zinc levels in individuals living with migraine disease compared to healthy controls, 11 and that zinc supplementation diminished migraine frequency and severity 12,13 . These studies, however, focused on zinc supplementation in individuals with migraine disease rather than dietary zinc consumption in the general population.…”

Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial

“…A comprehensive systematic review and meta-analysis conducted by Asbaghi et al [ 74 ] showed that lipid profiles may be affected by zinc supplementation. In women with migraines, serum LDL and TCH levels also decreased after zinc supplementation [ 75 ]. Zinc supplementation also decreased ALT and AST levels in rats with nonalcoholic steatohepatitis [ 76 ].…”

Migraine and zinc deficiency in women - A mini review

“…22 This study was also supported by an assessment study of the effect of Zinc in adult women for 12 weeks and revealed similar results as Zinc supplementation have promising effects on migraine frequency and severity. 23 Although these studies are preliminary with a limited number of patients and duration, an investigation with varying dosage and a more extended period of Zinc intervention may reveal a robust understanding of dietary Zinc for migraineurs.…”