Assessing the Efficacy of Nitazoxanide in Treatment of Cryptosporidiosis Using PCR Examination

Atia, Mahmoud M.; FATTAH, MOHIEDDIN ABDUL; RAHMAN, HANAN ABDEL; Mohammed, Faten Fawzy; GHANDOUR, ASMAA AL

doi:10.21608/jesp.2016.88325

Cited by 7 publications

(3 citation statements)

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“…Several drugs have been examined for their efficiency against cryptosporidiosis (Abdou et al, 2013). Only nitazoxanide is approved by the FDA to treat cryptosporidiosis in immunocompetent individuals but not for immunocompromised individuals (Gargala 2008 andAtia et al 2016). It affects the parasite by blocking its metabolism-necessary anaerobic energy, enhancing its clearance.…”

Section: Discussionmentioning

confidence: 99%

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Anti-cryptosporidial activity of Camellia sinensis (green tea extract) in experimentally infected immunocompromised mice

et al. 2022

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Cryptosporidium parvum, an Apicomplexan parasite, is an important cause of diarrheal disease,especially in immunodeficient hosts. Nevertheless, there is no entirely successful therapeutic agent against cryptosporidiosis to date. Hence, this study aims to test the potential prophylactic and therapeutic effect of Camellia sinensis (green tea extract) in dexamethasone immunosuppressed mice versus the nowadays used drug, Nitazoxanide (NTZ).Parasitological and molecular methods were used to characterize Cryptosporidium oocysts before infection. Fifty bred femaleSwissAlbino mice were divided into 5 groups; group I (GI)(GTP):immunosuppressed and prophylactically treated with green tea extractfor 5 days prior to infection,group II (GII)(GTT):immunosuppressed, infected with Cryptosporidium parvum and treated with green tea extract, group III (GIII)(NT): immunosuppressed, infected and treated with NTZ, group IV (GIV)(PC): immunosuppressed and infected (Positive control), group V (GV)(NC): immunosuppressed and non-infected (Negative control).Furthermore, parasitological examination for oocysts in the stool, and histopathological examination for the small intestine and liver specimens were performed for the study groups.Cryptosporidium oocysts used for induction of infection proved to beCryptosporidium parvumgenotype 2. Moreover, a significant oocyst reduction in fecal samples correlated with an improvement of histopathological changesin the small intestinal and liver tissues in GI(GTP), GII(GTT)and GIII(NT) groups. Besides, the GII(GTT)group showed the best improvement inparasitological andhistopathological parametersamong the test groups.This study revealed that Camellia sinensis(green tea extract) has potential activity against cryptosporidiosis and could serve as a promising prophylactic and therapeutic anti-cryptosporidial agent.

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Section: Discussionmentioning

confidence: 99%

“…Nitazoxanide (NTZ) is the only drug approved by Food and Drug Administration (FDA) in immunocompetent patients but has not demonstrated adequate results in children and immunodeficient patients, and there is no FDA-approved vaccine (Atia et al 2016;Ashigbie et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Anti-cryptosporidial activity of Camellia sinensis (green tea extract) in experimentally infected immunocompromised mice

et al. 2022

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“…Cryptosporidiosis is resistant to the majority of chemotherapeutic agents used to treat parasitic diseases. The current therapeutic drug (NTZ) has been approved by the Food and Drug Administration (FDA) for Cryptosporidium infection, on the other hand, it only shows moderate effectiveness in immunocompetent children and produces no benefit in immunosuppressed patients (Atia et al, 2016). Finding a reliable drug remains an important goal (Mead and Arrowood 2014;Widmer et al, 2020).…”

Section: Histopathological Studymentioning

confidence: 99%

Control of the Waterborne Cryptosporidiosis: Evaluation of the Protective Role of Cryptosporidium parvum Oocysts Antigen in Infected Immunocompetent and Immunosuppressed Mice

al.¹

2022

Egypt. J. of Aquatic Biolo. and Fish.

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Cryptosporidium sp. is a protozoan parasite that causes diarrheal disease (cryptosporidiosis) in humans by infecting the epithelial cells of the small intestine (Huston & Petri 2001). One of 2 species of Cryptosporidium infect human: C. hominis which is transmitted primarily person to person or C. parvum, a species that can be transmitted person to person or zoonotically (Priest et al., 2001; Frost et al., 2004).

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Evaluation of possible prophylactic and therapeutic effect of mefloquine on experimental cryptosporidiosis in immunocompromised mice

2020

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Assessing the Efficacy of Nitazoxanide in Treatment of Cryptosporidiosis Using PCR Examination

Cited by 7 publications

References 0 publications

Anti-cryptosporidial activity of Camellia sinensis (green tea extract) in experimentally infected immunocompromised mice

Anti-cryptosporidial activity of Camellia sinensis (green tea extract) in experimentally infected immunocompromised mice

Control of the Waterborne Cryptosporidiosis: Evaluation of the Protective Role of Cryptosporidium parvum Oocysts Antigen in Infected Immunocompetent and Immunosuppressed Mice

Evaluation of possible prophylactic and therapeutic effect of mefloquine on experimental cryptosporidiosis in immunocompromised mice

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