The World Health Organization (WHO) characterized COVID-19 as a pandemic, pointing to over 3 million cases and 207,973 deaths in 213 countries and territories on 11th March 2020. The COVID-19 pandemic is a catastrophic occurrence that has not been seen since the Spanish Flu. The infection has not only become a public health crisis but also affected the global economy. The objective of this paper is to determine the challenges faced in managing COVID-19 pandemic in Malaysia. In this research, the secondary data was used by reviewing through the articles and journals. Content analysis was made and the outcomes of this research have successfully emerged. As a result, the most significant challenges identified in managing COVID-19 pandemic in Malaysia are Financial Resources, Health Care System, Social Challenges, Education System, and Threats to Mental Health.