Assessing the global and local roles of TGF-β in early pancreatic oncogenesis and inflammation

Principe, Daniel R.; Mascarinas, Windel E.; Bauer, Jessica; Adrian, Kevin; Wayne, Elizabeth A.; Jung, Barbara; Grippo, Paul J.

doi:10.1016/j.pan.2012.12.287

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Phosphatase Regulation Of Tgf-β Signaling1

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2014

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“…The many interactions between TGF-β and ERK are extremely complex, and this PP2A-mediated phenomenon has not been sufficiently explored in other cell types. As mentioned, it has also been demonstrated that TGFBR1 can directly lead to ERK activation (40) and is a necessary in vivo activator of ERK in the pancreas (73). This suggests that ERK may also have roles in TGF-β-induced growth suppression.…”

Section: Phosphatase Regulation Of Tgf-β Signalingmentioning

confidence: 78%

TGF- : Duality of Function Between Tumor Prevention and Carcinogenesis

Principe

Doll

Bauer

et al. 2014

JNCI Journal of the National Cancer Institute

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453

411

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Several mechanisms underlying tumor progression have remained elusive, particularly in relation to transforming growth factor beta (TGF-β). Although TGF-β initially inhibits epithelial growth, it appears to promote the progression of advanced tumors. Defects in normal TGF-β pathways partially explain this paradox, which can lead to a cascade of downstream events that drive multiple oncogenic pathways, manifesting as several key features of tumorigenesis (uncontrolled proliferation, loss of apoptosis, epithelial-to-mesenchymal transition, sustained angiogenesis, evasion of immune surveillance, and metastasis). Understanding the mechanisms of TGF-β dysregulation will likely reveal novel points of convergence between TGF-β and other pathways that can be specifically targeted for therapy.

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Section: Phosphatase Regulation Of Tgf-β Signalingmentioning

confidence: 78%