2020
DOI: 10.1101/2020.03.04.975177
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Assessing the Heterogeneity of Cardiac Non-myocytes and the Effect of Cell Culture with Integrative Single Cell Analysis

Abstract: Cardiac non-myocytes comprise a diverse and crucial cell population in the heart that plays dynamic roles in cardiac wound healing and growth. Non-myocytes broadly fall into four cell types: endothelium, fibroblasts, leukocytes, and pericytes. Here we characterize the diversity of the non-myocytes in vivo and in vitro using mass cytometry. By leveraging single-cell RNA sequencing we inform the design of a mass cytometry panel. To aid in annotation of the mass cytometry datasets, we utilize data integration wit… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2021
2021
2022
2022

Publication Types

Select...
1
1

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(2 citation statements)
references
References 18 publications
0
2
0
Order By: Relevance
“…To illustrate the local publication landscape, the app provides a visualization of the article ‘s position within our training data. We used SAUCIE [60], an autoencoder designed to cluster single cell RNA-seq data, to build a two-dimensional embedding space that could be applied to newly generated preprints without retraining, a limitation of other approaches that we explored for visualizing entities expected to lie on a nonlinear manifold. We trained this model on document embeddings of PMC articles that did not contain a matching preprint version.…”
Section: Methodsmentioning
confidence: 99%
“…To illustrate the local publication landscape, the app provides a visualization of the article ‘s position within our training data. We used SAUCIE [60], an autoencoder designed to cluster single cell RNA-seq data, to build a two-dimensional embedding space that could be applied to newly generated preprints without retraining, a limitation of other approaches that we explored for visualizing entities expected to lie on a nonlinear manifold. We trained this model on document embeddings of PMC articles that did not contain a matching preprint version.…”
Section: Methodsmentioning
confidence: 99%
“…The app provides a visualization of the article’s position within our training data to illustrate the local publication landscape. We used SAUCIE [ 63 ], an autoencoder designed to cluster single-cell RNA-seq data, to build a two-dimensional embedding space that could be applied to newly generated preprints without retraining, a limitation of other approaches that we explored for visualizing entities expected to lie on a nonlinear manifold. We trained this model on document embeddings of PMC articles that did not contain a matching preprint version.…”
Section: Methodsmentioning
confidence: 99%