Assessing the impact of antiviral drugs commonly utilized during the COVID-19 pandemic on the embryonic development of Xenopus laevis

Laçin, Cemal; Turhan, Duygu Ozhan; Güngördü, Abbas

doi:10.1016/j.jhazmat.2024.134462

Journal of Hazardous Materials

2024

DOI: 10.1016/j.jhazmat.2024.134462

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Assessing the impact of antiviral drugs commonly utilized during the COVID-19 pandemic on the embryonic development of Xenopus laevis

Cemal Laçin,

Duygu Ozhan Turhan,

Abbas Güngördü

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Cited by 3 publications

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Which emerging micropollutants deserve more attention in wastewater in the post-COVID-19 pandemic period? Based on distribution, risk, and exposure analysis

Xia,

Mu,

et al. 2024

Science of The Total Environment

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Which emerging micropollutants deserve more attention in wastewater in the post-COVID-19 pandemic period? Based on distribution, risk, and exposure analysis

Xia,

Mu,

et al. 2024

Science of The Total Environment

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Occurrence and environmental fate of anti-influenza drugs in a subcatchment of the Yodo River Basin, Japan

Azuma,

Usui,

Hasei

et al. 2024

Science of The Total Environment

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Evidence of Oxidative Stress as a Mechanism of Pharmaceutical-Induced Toxicity in Amphibians

Cardoso-Vera,

Islas-Flores,

Pérez-Alvarez

et al. 2024

Antioxidants

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Amphibians, which are essential components of ecosystems, are susceptible to pharmaceutical contamination, a phenomenon of increasing concern owing to the widespread consumption and detection of pharmaceutical compounds in environmental matrices. This review investigates oxidative stress (OS) as the primary mechanism of drug toxicity in these organisms. The evidence gathered reveals that various pharmaceuticals, from antibiotics to anesthetics, induce OS by altering biomarkers of oxidative damage and antioxidant defense. These findings underscore the deleterious effects of pharmaceuticals on amphibian health and development and emphasize the necessity of incorporating OS biomarkers into ecotoxicological risk assessments. Although further studies on diverse amphibian species, drug mixtures, and field studies are required, OS biomarkers offer valuable tools for identifying sublethal risks. Furthermore, the development of more refined OS biomarkers will facilitate the early detection of adverse effects, which are crucial for protecting amphibians and their ecosystems. Ultimately, this review calls for continued research and mitigation strategies to safeguard biodiversity from pharmaceutical contamination.

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Assessing the impact of antiviral drugs commonly utilized during the COVID-19 pandemic on the embryonic development of Xenopus laevis

Cited by 3 publications

References 61 publications

Which emerging micropollutants deserve more attention in wastewater in the post-COVID-19 pandemic period? Based on distribution, risk, and exposure analysis

Which emerging micropollutants deserve more attention in wastewater in the post-COVID-19 pandemic period? Based on distribution, risk, and exposure analysis

Occurrence and environmental fate of anti-influenza drugs in a subcatchment of the Yodo River Basin, Japan

Evidence of Oxidative Stress as a Mechanism of Pharmaceutical-Induced Toxicity in Amphibians

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