The COVID-19 pandemic has brought unprecedented challenges and stressors for social workers, often at the forefront of responding to crises. The pandemic has disrupted their professional practices, increased their workload, and exposed them to health risks. As a result, the well-being of social workers has become a growing concern, especially in countries with limited resources. The present study used a cross-sectional web-based survey to assess the prevalence rates of anxiety, stress, sleep quality, and overall well-being in a sample of 216 social workers employed in public medical facilities in Egypt during the COVID-19 epidemic. It also investigated the factors that influence their well-being. The results showed that half of the social workers (51.4%) scored 10 or higher on the General Anxiety Disorder scale (GAD-7), 83.3% scored ≥ 14 on PSS-10, and the mean score for sleep quality was 7.24 (SD = 2.10). Over half (58.3%) scored 50 or lower on the World Health Organization Wellbeing scale (WHO-5). Multivariable logistic regression analysis showed that younger social workers and those who scored ≤ 9 on GAD-7 were more likely to report a higher level of well-being. A higher score on PSS-10 was associated with a decrease in overall well-being. Working with family members of COVID-19 patients and sleep quality were not associated with WHO-5. These findings highlight the significant impact of the COVID-19 pandemic on the mental health of social workers in Egypt, underscoring the importance of providing adequate support and resources to address their well-being.