Assessing the impact of essential tremor on upper limb function

Bain, Peter G.; Málly, Judit; Gresty, Michael A.; Findley, Leslie J.

doi:10.1007/bf00870673

Cited by 98 publications

(57 citation statements)

References 17 publications

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“…The tremor had to be of gradual onset (i.e., slow and progressive) and either (1) present for at least 1 year or (2) accompanied by a family history of the same disorder (one or more reportedly affected first-degree relatives) [9,16] . On an Archimedes spiral, tremor severity had to be moderate or greater (rating 6 2 on the handwriting scale of Bain and Findley [17] ). Based on their medical history, participants were not considered to have ET if their tremor was related to alcohol withdrawal, hyperthyroidism, anxiety, or medications.…”

Section: Diagnosesmentioning

confidence: 99%

Antihypertensive Agents and Risk of Parkinson’s Disease, Essential Tremor and Dementia: A Population-Based Prospective Study (NEDICES)

2009

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Background: Recent interest in antihypertensive agents, especially calcium channel blockers, has been sparked by the notion that these medications may be neuroprotective. A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson’s disease (PD) or dementia. There are no data for essential tremor (ET). Objective: To examine the association between antihypertensive use (defined broadly and by individual subclasses) and ET, PD and dementia. For each disorder, we used cross-sectional data (association with prevalent disease) and prospective data (association with incident disease). Methods: Prospective population-based study in Spain enrolling 5,278 participants at baseline. Results: Use of antihypertensive medications (aside from β-blockers) was similar in prevalent ET cases and controls. Baseline use of antihypertensive agents was not associated with reduced risk of incident ET. Antihypertensive medication use was not associated with prevalent or incident PD. Calcium channel blocker use was marginally reduced in prevalent dementia cases (OR_adjusted = 0.63, p = 0.06) but was not associated with reduced risk of incident dementia (RR_adjusted = 1.02, p = 0.95). Conclusions: We did not find evidence of a protective effect of antihypertensive medications in these three neurodegenerative disorders.

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Section: Diagnosesmentioning

confidence: 99%

Antihypertensive Agents and Risk of Parkinson’s Disease, Essential Tremor and Dementia: A Population-Based Prospective Study (NEDICES)

2009

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“…The following assessments are recommended to document the effect of surgical procedures: (1) clinical (0-10) ratings of the severity of different tremor components present in different body parts, [40][41][42] (2) 0 to 10 ratings of tremor in spirals and handwriting samples, [40][41][42] (3) a tremor-related disability and handicap questionnaire, 43 (4) nine-hole pegboard test, and (5) Short Form-36 (SF-36) and Sickness Impact Profile (SIPS) questionnaires. In most instances accelerometry does not provide any useful functional information about the effects of thalamic stimulation on essential tremor, but may be of research interest.…”

Section: Specific Assessmentmentioning

confidence: 99%

“…(2) Upper limb postural tremors' frequencies are measured by using uni-axial miniature accelerometers, using a technique previously described. 40,41 (3) A visually guided computerised tracking task. 55 (4) 0 to 10 ratings of tremor in spirals and handwriting samples.…”

Section: Specific Assessmentsmentioning

confidence: 99%

Deep brain stimulation for trauma: Patient selection and evaluation

Deuschl

Bain

2002

Mov Disord.

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The selection of patients with movement disorders for deep brain stimulation is becoming a common neurological and neurosurgical task. Deep brain stimulation is suitable for different forms of tremor, which can often not be treated with medication. This suitability applies for essential tremor, monosymptomatic tremor at rest, cerebellar or multiple sclerosis tremor, Holmes' tremor, primary writing tremor or tremor in neuropathies. The appropriate selection of patients is critical for the outcome of surgical relief of tremors. Considering the risks of any stereotactic intervention, the following must apply: (1) motor symptoms lead to a relevant disability in activities of daily living, despite optimal medical treatment; (2) biological age of the patient; (3) neurosurgical contraindications; (4) the patient is neither demented nor severely depressed. If these conditions are fulfilled, the individual chances of improvement of the target symptoms need to be checked, based on the following guidelines: (1) the kind of tremor, (2) the natural course of the tremor, (3) the chances for medical treatment in a particular patient, (4) the outcome of surgery in a specific condition, (5) the individual risks for a patient to suffer from complications. The outcome of surgery for tremor depends on the clinical type and distribution. Distal limb tremors are easier to treat than proximal limb tremors. Intention tremor is more difficult to treat than rest or postural tremor. The indication for surgical treatment depends on the analysis of the individual risk-benefit ratio, which also has to take into account the patients' social, professional, and familial background. The patient needs to be well informed about his individual risk-benefit ratio and of alternative treatments, before undergoing stereotactic surgery.

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“…The hallmark feature of ET is kinetic tremor, which may be associated with varying degrees of functional disability [2][3][4]. The etiology of ET is complex; both genetic and environmental factors are likely contributors [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Essential Tremor in the Faroe Islands: A Population-Based Study

et al. 2019

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Background: No studies of the prevalence of one of the most common movement disorders, essential tremor (ET), have been undertaken in the Faroe Islands. Given the potential for founder effects in the Islands, and the highly genetic nature of ET, the Faroe Islands provide a particularly interesting setting in which to study the prevalence of ET. Objective: To estimate the prevalence of ET and study its characteristics. Methods: We used a 2-phase, population-based design, screening 1,328 randomly selected Faroese individuals aged ≥40 years. A subsample of 282 individuals who had returned the spirals and questionnaire was selected to participate in an in-person clinical evaluation. Tremor was systematically quantified by a senior movement disorder neurologist with particular specialization in tremor using a reliable and valid clinical rating scale followed by the application of rigorous diagnostic criteria used by tremor investigators internationally. Results: The overall crude prevalence was 2.9%. The age-adjusted prevalence was 3.1%. There was an age-associated rise in prevalence; by age ≥70, prevalence reached 4.8%. Twenty six of 27 (96.2%) were previously undiagnosed. Conclusions: This is the first population-based study of the prevalence of ET in the Faroe Islands. The estimated prevalence was similar to studies using the same or comparable methodologies.

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Assessing the impact of essential tremor on upper limb function

Cited by 98 publications

References 17 publications

Antihypertensive Agents and Risk of Parkinson’s Disease, Essential Tremor and Dementia: A Population-Based Prospective Study (NEDICES)

Antihypertensive Agents and Risk of Parkinson’s Disease, Essential Tremor and Dementia: A Population-Based Prospective Study (NEDICES)

Deep brain stimulation for trauma: Patient selection and evaluation

Prevalence of Essential Tremor in the Faroe Islands: A Population-Based Study

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