Assessing the Impact of Increasing Antimicrobial Resistance of <i>Vibrio cholerae</i> on the Future Trends of Cholera Epidemic

Mushayabasa, Steady; Bhunu, C. P.

doi:10.5402/2012/127492

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…The emergence of antimicrobial resistance among Vibrio cholerae is a burden on public health especially in developing countries (Das et al, 2019). An increase in the incidence of multidrug resistance V. cholerae could hurt cholera-controlling measures within a community (Mushayabasa and Bhunu, 2012). To subdue the emergence of antibiotic resistance, natural compounds that exert anti-virulence properties have been recognized as an alternative strategy (Narendrakumar et al, 2019a).…”

Section: Discussionmentioning

confidence: 99%

Exploration of Anti-infectives From Mangrove-Derived Micromonospora sp. RMA46 to Combat Vibrio cholerae Pathogenesis

et al. 2020

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Vibrio cholerae, the etiological agent of cholera, employs quorum sensing (QS) pathways to control the expression of virulence factors, including the production of cholera toxin and biofilm formation. Acquired antibiotic resistance in V. cholerae draws attention to the development of novel therapeutics that counteract virulence, rather than the viability of the pathogen. In this context, we explored the anti-infective potential of rare marine Actinobacteria (RMA) from a mangrove ecosystem. Here, we report the effects of Micromonospora sp. RMA46 against V. cholerae in vitro. The RMA46 organic extract was non-bactericidal to V. cholerae cells and non-cytotoxic to macrophage RAW264.7 cell lines. RMA46 inhibited the formation of V. cholerae biofilms and downregulated the QS global switches LuxO and HapR, as well as other virulence genes including ct, tcp, and hapA. In silico molecular docking simulation of RMA46 ethyl acetate extract with LuxO and HapR revealed that 2-methoxy-4-vinylphenol and hexahydro-3-(phenylmethyl)-pyrrolo[1,2-a]pyrazine-1,4-dione could interact with the active sites of LuxO and HapR and potentially inhibit them. This study highlights Micromonospora sp. RMA46 as a potential source of anti-infectives against V. cholerae.

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Section: Discussionmentioning

confidence: 99%

Exploration of Anti-infectives From Mangrove-Derived Micromonospora sp. RMA46 to Combat Vibrio cholerae Pathogenesis

et al. 2020

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“…In order to examine the global stability of E 0 c we use the method proposed by Kamgang and Sallet (2008). By closely following Kamgang and Sallet (2008) [25][26][27], we write system (1) in the form…”

Section: Disease-free Equilibrium and Itsmentioning

confidence: 99%

A Mathematical Model for Assessing the Impact of Intravenous Drug Misuse on the Dynamics of HIV and HCV within Correctional Institutions

Mushayabasa

Bhunu

Stewart

2012

ISRN Biomathematics

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Unsafe injecting practices, blood exchange, the use of nonsterile needles, and other cutting instruments for tattooing are common in correctional institutions, resulting in a number of blood transmitted infections. A mathematical model for assessing the dynamics of HCV and HIV coinfection within correctional institutions is proposed and comprehensively analyzed. The HCVonly and HIV-only submodels are first considered. Analytical expressions for the threshold parameter in each submodel and the cointeraction are derived. Global dynamics of this coinfection shows that whenever the threshold parameter for the respective submodels and the coinfection model is less than unity, then the epidemics die out, the reverse condition implies disease persistence within correctional institutions. Numerical simulations using a set of plausible parameter values are provided to support analytical findings.

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Mathematical modeling of cholera dynamics in the presence of antimicrobial utilization strategy

Mushanyu,

Matsebula,

Nyabadza

2024

Sci Rep

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Antimicrobial resistance poses a significant threat to public health, particularly in cholera treatment. The emergence of antibiotic resistance, coupled with the sharp decline in pharmaceutical companies developing new cholera antibiotics, is a cause for concern. We formulate a multidrug-resistant (MDR) cholera epidemic model that incorporates a stage-switching strategy between two antibiotics to reduce the magnitude of resistance. The model is analyzed mathematically, and sensitivity analysis of the reproduction number is performed using sub-reproduction numbers. Stability analysis of the cholera-sensitive-only and cholera-resistant-only equilibria is investigated using Centre Manifold Theory. The model is calibrated through Markov Chain Monte Carlo simulations in Stan, showing stability at equilibrium points, which is further verified through numerical simulations. The simulations demonstrate an inverse relationship between the number of MDR cholera cases and the number of individuals receiving second-line treatment for cholera. This study suggests that the correct use of antibiotics can effectively manage the emergence of antimicrobial resistance. From a public health policy perspective, these findings emphasize the importance of antibiotic stewardship programs and the need for policies that promote the responsible use of existing antibiotics while encouraging the development of new treatment options. Such measures could help mitigate the global burden of MDR cholera and prevent further escalation of resistance.

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Assessing the Impact of Increasing Antimicrobial Resistance of Vibrio cholerae on the Future Trends of Cholera Epidemic

Cited by 4 publications

References 16 publications

Exploration of Anti-infectives From Mangrove-Derived Micromonospora sp. RMA46 to Combat Vibrio cholerae Pathogenesis

Exploration of Anti-infectives From Mangrove-Derived Micromonospora sp. RMA46 to Combat Vibrio cholerae Pathogenesis

A Mathematical Model for Assessing the Impact of Intravenous Drug Misuse on the Dynamics of HIV and HCV within Correctional Institutions

Mathematical modeling of cholera dynamics in the presence of antimicrobial utilization strategy

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