Assessing the impact of insecticide-treated nets in the face of insecticide resistance on malaria control

Ngonghala, Calistus N.

doi:10.1016/j.jtbi.2022.111281

Cited by 8 publications

(9 citation statements)

References 100 publications

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“…As mentioned before, one of the leading mitigation measures over time has been the use of ITNs, which has had a significant impact in the reduction of malaria cases, in combination with other mitigation strategies [ 1 , 7 , 12 , 14 , 41 ]. This result has been supported and analyzed by mathematical models [ 35 , 42 , 43 , 44 , 45 , 46 ].…”

Section: Introductionmentioning

confidence: 56%

“…Compartmental mathematical models for vector-borne diseases are vastly found in the literature [ 31 , 32 , 33 ], and are mainly based on and inspired by the Ross–McDonald malaria model [ 34 ]. In particular, there is a significant number of articles associated with mathematical modeling of malaria dynamics [ 35 , 36 , 37 , 38 , 39 , 40 ]. The behavior of the disease in humans is generally expressed through an SEIR-type model, while the vector follows SI-type dynamics [ 36 , 37 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

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Collateral Effects of Insecticide-Treated Nets on Human and Environmental Safety in an Epidemiological Model for Malaria with Human Risk Perception

Gutiérrez-Jara

Vogt-Geisse

Cabrera

2022

IJERPH

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Malaria remains a major health problem in many parts of the world, including Sub-Saharan Africa. Insecticide-treated nets, in combination with other control measures, have been effective in reducing malaria incidence over the past two decades. Nevertheless, there are concerns about improper handling and misuse of nets, producing possible health effects from intoxication and collateral environmental damage. The latter is caused, for instance, from artisanal fishing. We formulate a model of impulsive differential equations to describe the interplay between malaria dynamics, human intoxication, and ecosystem damage; affected by human awareness to these risks and levels of net usage. Our results show that an increase in mosquito net coverage reduces malaria prevalence and increases human intoxications. In addition, a high net coverage significantly reduces the risk perception to disease, naturally increases the awareness for intoxications from net handling, and scarcely increases the risk perception to collateral damage from net fishing. According to our model, campaigns aiming at reducing disease prevalence or intoxications are much more successful than those creating awareness to ecosystem damage. Furthermore, we can observe from our results that introducing closed fishing periods reduces environmental damage more significantly than strategies directed towards increasing the risk perception for net fishing.

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Section: Introductionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Collateral Effects of Insecticide-Treated Nets on Human and Environmental Safety in an Epidemiological Model for Malaria with Human Risk Perception

Gutiérrez-Jara

Vogt-Geisse

Cabrera

2022

IJERPH

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“…Similar to many traditional malaria models, when the reproduction number is below unity, there exists a parameter range where disease containment is possible and another range where a backward bifurcation occurs. As in [39, 42, 43, 45], the backward bifurcation occurs when the human disease-induced mortality rate is significantly higher than the human natural mortality rate. This backward bifurcation phenomenon implies that achieving disease elimination requires intensified and sustained control measures until the reproduction number drops below a critical threshold and hence a push to lower transmission levels.…”

Section: Discussion Limitations and Conclusionmentioning

confidence: 99%

“…In particular, much of the mathematical modeling literature on malaria and vector-borne diseases in general builds on the Ross-Macdonald framework for malaria of the 1900s [32, 33]. This basic but useful framework has been extended in various ways to account for more epidemiological and immunological aspects of malaria (e.g., [33–36]), demographic and feeding patterns of mosquitoes (e.g., [37–41]), environmental factors such as temperature (e.g., [42–46]), and various control and mitigation measures including the use of insecticide-treated nets and indoor residual spraying (e.g., [47–52])…”

Section: Introductionmentioning

confidence: 99%

Modeling the synergistic interplay between malaria dynamics and economic growth

Ngonghala,

Enright,

Prosper

et al. 2023

Preprint

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The mosquito-borne disease (malaria) imposes significant challenges on human health, healthcare systems, and economic growth/productivity. This study develops and analyzes a model to understand the interplay between malaria dynamics, economic growth, and transient events. The study uncovers varied effects of disease and economic parameters on model outcomes, highlighting the interdependence of the reproduction number (R0) on both disease and economic factors, and a reciprocal relationship where malaria diminishes economic productivity, while higher economic output is associated with reduced malaria prevalence. This emphasizes the intricate interplay between malaria dynamics and socio-economic factors. Also, the study offers insights into malaria control and underscores the significance of optimizing external aid allocation, especially favoring an even distribution strategy, with the most significant reduction observed in the equal monthly distribution strategy compared to longer distribution intervals. Furthermore, the study shows that controlling malaria in high mosquito biting areas with limited aid, low technology, inadequate treatment, or low economic investment is challenging. The model exhibits a backward bifurcation implying that sustainability of control and mitigation measures is essential even whenR0is slightly less than one. Additionally, there is a parameter regime for which long transients are feasible. Long transients are critical for predicting the behavior of dynamic systems and identifying factors influencing transitions; they reveal reservoirs of infection, vital for disease control. Policy recommendations include prioritizing sustained control measures, optimizing external aid allocation, and reducing mosquito biting for effective disease control.

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“…Among those ITNs and LLINs were strongly recommended [9,25]. Several research have been made on the efficacy of ITNs and other preventive and control measures in the recent past based on small local sample quantity and review of previous studies [26][27][28][29][30][31]. Additionally, very few research works did comparative studies on major preventive and control measures based on metaanalysis [32,33].…”

Section: Introductionmentioning

confidence: 99%

Malaria incidence and prevalence: An ecological analysis through Six Sigma approach

Al-Amin,

Vijaya Bhaskar,

Enab

et al. 2024

EUR J ENV PUBLIC HLT

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Malaria is the leading cause of death globally, especially in sub-Saharan African countries claiming over 400,000 deaths globally each year, underscoring the critical need for continued efforts to combat this preventable and treatable disease. The objective of this study is to provide statistical guidance on the optimal preventive and control measures against malaria. Data have been collected from reliable sources, such as World Health Organization, UNICEF, Our World in Data, and STATcompiler. Data were categorized according to the factors and sub-factors related to deaths caused by malaria. These factors and sub-factors were determined based on root cause analysis and data sources. Using JMP 16 Pro software, both linear and multiple linear regression were conducted to analyze the data. The analyses aimed to establish a linear relationship between the dependent variable (malaria deaths in the overall population) and independent variables, such as life expectancy, malaria prevalence in children, net usage, indoor residual spraying usage, literate population, and population with inadequate sanitation in each selected sample country. The statistical analysis revealed that using insecticide treated nets (ITNs) by children and individuals significantly decreased the death count, as 1,000 individuals sleeping under ITNs could reduce the death count by eight. Based on the statistical analysis, this study suggests more rigorous research on the usage of ITNs.

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Assessing the impact of insecticide-treated nets in the face of insecticide resistance on malaria control

Cited by 8 publications

References 100 publications

Collateral Effects of Insecticide-Treated Nets on Human and Environmental Safety in an Epidemiological Model for Malaria with Human Risk Perception

Collateral Effects of Insecticide-Treated Nets on Human and Environmental Safety in an Epidemiological Model for Malaria with Human Risk Perception

Modeling the synergistic interplay between malaria dynamics and economic growth

Malaria incidence and prevalence: An ecological analysis through Six Sigma approach

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