2011
DOI: 10.1186/1742-4690-8-s2-o15
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Assessing the impact of lentiviral vector integration on splicing of cellular genes at the genome-wide level

Abstract: Oncogenesis induced by insertional mutagenesis with gene therapy vectors occurs mainly by activation of proto-oncogenes found at or nearby the insertion site. This activation often occurs by an enhancer-mediated mechanism or by a process of splicing capture which generates chimeric transcripts comprising portions of vector and cellular mRNAs. Although the activation of oncogenes may be reduced by the use of self-inactivating design and moderate cellular promoters, how to reduce genotoxic splicing capture event… Show more

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“…Membrane binding is mediated by Gag’s N-terminal myristoylated MA domain [myr(+)MA; Adamson and Freed, 2007; Ganser-Pornillos et al, 2008; Ono, 2009; Chukkapalli and Ono, 2011; Hamard-Peron and Muriaux, 2011]. The myristyl (myr) group functions in concert with a group of conserved basic residues to facilitate membrane anchoring and assembly of Gag.…”
mentioning
confidence: 99%
“…Membrane binding is mediated by Gag’s N-terminal myristoylated MA domain [myr(+)MA; Adamson and Freed, 2007; Ganser-Pornillos et al, 2008; Ono, 2009; Chukkapalli and Ono, 2011; Hamard-Peron and Muriaux, 2011]. The myristyl (myr) group functions in concert with a group of conserved basic residues to facilitate membrane anchoring and assembly of Gag.…”
mentioning
confidence: 99%