In this paper, we analyze the effects of co-residence with elderly parents on gender differences in travel. The Household Responsibility Hypothesis (HRH) explains differences in the role of women regarding household responsibilities. However, research so far has studied "Western" household types while excluding households with coresiding elderly parents. Furthermore, research has paid exclusive attention to gender differences in commuting trips, and has neglected the effects of built environment characteristics. In view of these shortcomings, we pose the following research questions: what are the determinants of gendered differences in travel behavior, and specifically, what are the effects of elderly co-residence in households and land use on gender differences in trip frequency and travel distance? In addition to the HRH, we introduce the Elderly Co-residence Hypothesis, which suggests that co-residing elderly parents take over household responsibilities from adult women, resulting in diminishing gender differences in working-age travel patterns. We present the results of empirical research in Nanjing, China, that support this hypothesis.