Assessing the Impact of Lupus Nephritis in a Childhood-Onset Systemic Lupus Erythematosus Cohort

Sakamoto, Ana Paula; Silva, Liana Soido Teixeira E; Terrazas, Ana Maria; Len, Cláudio Arnaldo; Silva, Clovis Artur Almeida Da; Terreri, Maria Teresa

doi:10.5151/sbr2019-343

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With regard to mortality, a Norway-SLE cohort study showed that SMR was increased to 1.8 (95% CI 1.6–2.2) in incident adult-onset and peaked at 7.2 (95% CI 3.3–14) in cSLE patients [25 ▪ ]. Moreover, neuropsychiatric lupus (HR 2.56, 95% CI 1.48–4.42) and CKD (HR 4.33, 95% CI 2.33–4.72) were the main risk factors associated with mortality in a large cSLE cohort [26]. Other common causes of death include infection and vascular disease [2].…”

Section: Systemic Lupus Erythematosus Prognosis and Surveillancementioning

confidence: 95%

Updates in the care and management of children and adolescents with systemic lupus erythematosus

Silva,

Aikawa,

Bonfa

2024

Current Opinion in Rheumatology

View full text Add to dashboard Cite

Purpose of review This narrative review offers an update of the most important recent articles published in the previous year of childhood-onset systemic lupus erythematosus (cSLE), focusing on care and management. Recent findings Age-related disparities may play a significant role in the clinical and laboratory characteristics of cSLE, as well as its performance in distinct classification criteria. Monogenic lupus is associated with higher disease damage scores and mortality rate compared to sporadic cSLE. Adolescent face unique challenges, with comorbid psychiatric diagnosis, low resilience and nonadherence posing relevant challenges. A recent international task force has outlined pivotal principles and points-to-consider for treat-to-target (T2T) in cSLE patients. While the past year did yield new randomized controlled trial for cSLE treatment, publications focused on broader management strategies, including the impact of ultraviolet radiation exposure, immunization, and strict blood pressure control. Additionally, case reports and series have evaluated the efficacy/safety profiles of both available and emerging treatments. Summary Current studies highlighted the various facets of cSLE, epidemiology, clinical, laboratory, classification criteria, adolescent issues, prognosis, surveillance, T2T approach and drug management. Despite notable progress, the scarcity of randomized trials emphasizes the need to delineate safer and more efficacious treatment modalities in cSLE.

show abstract

Section: Systemic Lupus Erythematosus Prognosis and Surveillancementioning

confidence: 95%