Assessing the impact of perioperative blood transfusions on the survival of adults undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for appendiceal carcinomatosis

Owusu-Agyemang, Pascal; Zavala, Acsa M.; Williams, Uduak Ursula; Meter, Antoinette Van; Soliz, José; Kapoor, Ravish; Shah, Abhinit; Hernandez, Mike; Gottumukkala, Vijaya; Cata, Juan P.

doi:10.1111/vox.12546

Cited by 8 publications

(1 citation statement)

References 33 publications

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“…Although robust statistical methods are employed by both studies, it is impossible to completely rule out the effect residual confounding of unmeasured variables, particularly in the sicker patients. Similar to the findings of previous studies, higher-grade tumors, higher EBl, higher preoperative PLR and the presence of extra-abdominal disease were associated with reduced survival in our study [25][26][27].…”

Section: Discussionsupporting

confidence: 92%

An assessment of the survival impact of multimodal anesthesia/analgesia technique in adults undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a propensity score matched analysis

Cata

Nguyen

Ifeanyi-Pillette

et al. 2019

International Journal of Hyperthermia

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Background: Studies suggest volatile anesthetics and opioids may enhance the malignant potential of cancer cells. The objective of this single institution retrospective study was to evaluate the survival impact of a multimodal opioid-sparing nonvolatile anesthetic technique (MA) in a group of patients who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for appendiceal carcinomatosis. Methods: Propensity score matching (PSM) and Cox proportional hazard models were used to compare the survivals of patients who received MA (MA group), to those who received volatile-opioid anesthesia (volatile-opioid group). Results: Of the 373 patients, 110 (29%) were in the MA group and 263 (71%) in the volatile-opioid group. The MA group was older (mean ± standard deviation (SD): 55 ± 11 versus 53 ± 10 years, p ¼ .035) and had more patients with ASA scores 3 or 4 (90% versus 81%, p ¼ .032), and those with high grade tumors (18% versus 12%, p ¼ .009). Intraoperative opioid consumption was lower in the MA group (mean morphine equivalents ± SD: 13 ± 10 versus 194 ± 789, p < .0001). After PSM, 107 patients remained in each group. In the adjusted Cox proportional hazards model after PSM, MA was not associated with improved progression free survival (PFS) (HR 1.45, 95% CI [0.94-2.22], p ¼ .093) or overall survival (OS) (HR 1.66, 95% CI [0.86-3.20], p ¼ .128), when compared to volatile-opioid anesthesia. Conclusions: In this retrospective study, a multimodal opioid-sparing nonvolatile anesthetic approach was not associated with improved survival. Precis' statement: In this study of patients undergoing major cancer surgery, the use of multimodal anesthetic and analgesic agents, while avoiding volatile anesthetics and minimizing opioid use was not associated with improved survival. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 92%

An assessment of the survival impact of multimodal anesthesia/analgesia technique in adults undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a propensity score matched analysis

Cata

Nguyen

Ifeanyi-Pillette

et al. 2019

International Journal of Hyperthermia

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Red blood cell transfusions and the survival in patients with cancer undergoing curative surgery: a systematic review and meta-analysis

Petrelli

Ghidini

et al. 2021

Surg Today

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Intraoperative packed red blood cell transfusion (iPRBT) and PCI-normalised iPRBT rates (iPRBT/PCI ratio) negatively affect short- and long-term outcomes of patients undergoing cytoreductive surgery and intraperitoneal chemotherapy – An analysis of 880 patients

Fisher

Alzahrani

Kozman

et al. 2019

European Journal of Surgical Oncology

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Assessing the impact of perioperative blood transfusions on the survival of adults undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for appendiceal carcinomatosis

Abstract: In this retrospective study of adults who had undergone CRS-HIPEC for appendiceal carcinomatosis, PBT was not significantly associated with survival.

Cited by 8 publications

References 33 publications

An assessment of the survival impact of multimodal anesthesia/analgesia technique in adults undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a propensity score matched analysis

An assessment of the survival impact of multimodal anesthesia/analgesia technique in adults undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a propensity score matched analysis

Red blood cell transfusions and the survival in patients with cancer undergoing curative surgery: a systematic review and meta-analysis

Intraoperative packed red blood cell transfusion (iPRBT) and PCI-normalised iPRBT rates (iPRBT/PCI ratio) negatively affect short- and long-term outcomes of patients undergoing cytoreductive surgery and intraperitoneal chemotherapy – An analysis of 880 patients

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