Assessing the Impact of the Absence of Detrusor Muscle in Ta Low-grade Urothelial Carcinoma of the Bladder on Recurrence-free Survival

Mastroianni, Riccardo; Brassetti, Ado; Krajewski, Wojciech; Zdrojowy, Romuald; Salhi, Yazan Al; Anceschi, Umberto; Bove, Alfredo Maria; Carbone, Antonio; Nunzio, Cosimo De; Fuschi, Andrea; Ferriero, Mariaconsiglia; Nacchia, Antonio; Pastore, Antonio Luigi; Tema, Giorgia; Tuderti, Gabriele; Gallucci, Michele; Simone, Giuseppe

doi:10.1016/j.euf.2020.08.007

Cited by 21 publications

(17 citation statements)

References 27 publications

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“…Finally, studying the predictors of recurrence, particular emphasis should be applied to the question whether obtaining detrusor muscle in TURBT of bladder cancer specimens is considered a surrogate marker of resection quality [ 50 ].…”

Section: Future Directionsmentioning

confidence: 99%

Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study

Tarantino

Crocetto

Vito

et al. 2021

JCM

104

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Among risk factors (apart from smoking) likely involved in bladder cancer (BCa), metabolic syndrome (MS), obesity and type 2 diabetes mellitus (T2DM) have been explored with contrasting results. In spite of these studies, there is little data on the association between nonalcoholic fatty liver disease (NAFLD), its main driver, i.e., insulin resistance (IR), and BCa. Implanting a cross-sectional retrospective study we tried to investigate both NAFLD and IR prevalence in a hospital based population of BCa patients. We studied laboratory data from 204 patients with histologically confirmed non metastatic BCa and 50 subjects with no BCa, but with bladder diseases (no Ca BD). We evaluated the presence of NAFLD by the triglycerides/glucose Index (TyG Index), using a cut-off of 0.59 and by the Aspartate Aminotransferase/Alanine Aminotransferase AST/ALT ratio. IR was assessed by the same TyG Index (cut-off 4.68) and the triglycerides/High-Density Lipoprotein HDL ratio (cut-off 2.197). The diagnosis of impaired fasting glucose (IFG), condition of prediabetes, as well as that of T2DM was assessed according to canonical guidelines. The TyG Index predicted NAFLD presence in both groups (p = 0.000), but the BCa group showed a major percentage of NAFLD cases with respect to no Ca BD group (59% versus 40%). A greater proportion of IR (47%) in BCa group than in no Ca BD one (37%) was evidenced by the TyG Index with its median value significantly different (p = 0.0092). This high rate of IR in the BCa group was confirmed by the triglycerides/HDL ratio (p = 0.02). Prediabetes and T2DM were more prevalent in the BCa group than no Ca BD group (p = 0.024). In this study a consistent NAFLD presence was found in BCa patients. This is an important comorbidity factor that deserves further consideration in prospective studies. The higher prevalence of NAFLD, IR, prediabetes and T2DM in the BCa group evidences the need that these disorders should be reckoned as adjunct factors that could impact on this cancerous disease.

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Section: Future Directionsmentioning

confidence: 99%

Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study

Tarantino

Crocetto

Vito

et al. 2021

JCM

104

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“…Although the absence of muscularis propria in the first TURBT specimen is a clear indication for a restaging TURBT in T1 tumours, a similar benefit for Ta tumours is less clear. Therefore, in select cases of HG Ta (e.g., multiple and / or ≥ 3cm tumours), a restaging TURBT might be considered (LE 3; weak recommendation) 190,191 .…”

confidence: 99%

Canadian Urological Association guideline on the management of non-muscle invasive bladder cancer

Bhindi

Kool

Kulkarni

et al. 2021

CUAJ

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“…A similar benefit for Ta tumors, however, is less clear. 12,13 Therefore, in select cases of HG Ta (e.g., multiple and/or ≥3 cm tumors), a re-staging TURBT might be considered (LE 3, weak recommendation).…”

Section: Bhindi Et Almentioning

confidence: 99%

Canadian Urological Association guideline on the management of non-muscle-invasive bladder cancer – Abridged version

Bhindi¹,

Kool²,

Kulkarni³

et al. 2021

CUAJ

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Assessing the Impact of the Absence of Detrusor Muscle in Ta Low-grade Urothelial Carcinoma of the Bladder on Recurrence-free Survival

Cited by 21 publications

References 27 publications

Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study

Association of NAFLD and Insulin Resistance with Non Metastatic Bladder Cancer Patients: A Cross-Sectional Retrospective Study

Canadian Urological Association guideline on the management of non-muscle invasive bladder cancer

Canadian Urological Association guideline on the management of non-muscle-invasive bladder cancer – Abridged version

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