Recent advancements have led to a growing prevalence of studies examining ionospheric and atmospheric anomalies as potential precursors to earthquakes. In this context, the study involved analyzing variations in ionospheric total electron content (TEC), investigating anomalies, assessing space weather conditions, and examining changes in atmospheric parameters to evaluate potential precursors and post-seismic effects related to the Mw 7.7 and Mw 7.6 earthquakes that struck Kahramanmaraş consecutively in 2023. To compute the total electron content (TEC) values, data from 29 GNSS receivers covering a period of approximately 49 days were processed. In addition, since identical code signals were not available among all receiver stations, the study conducted an analysis of TEC estimations applying different GPS codes. To analyze space weather conditions, which are considered the main source of changes in the ionosphere, variations in sunspot number, solar activity index, magnetic activity indices (Kp and Dst), and geomagnetic field components were examined across the relevant period. To assess the potential presence of a distinct relationship between seismic activity at the Earth’s surface and ionospheric conditions, atmospheric parameters including temperature, relative humidity, and pressure were meticulously monitored and evaluated. As a result of the study, it was determined that TEC anomalies that could be evaluated as earthquake precursors independent of space weather conditions were observed starting from the 3rd day before the earthquake, and high positive TEC anomalies occurred immediately after the earthquakes. In atmospheric parameters, the change in behavior, particularly in temperature value, 10 days before the earthquake, is noteworthy.