Assessing the impact of the pandemic in children and adolescents: SARS-CoV-2 infection and beyond

Molteni, Erika; Absoud, Michael; Duncan, Emma L.

doi:10.1016/s2352-4642(22)00035-9

Cited by 8 publications

(11 citation statements)

References 8 publications

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“…response rates thus a better or worse representation of the entire paediatric population), gender imbalance, recall bias and the higher awareness for this syndrome due to extensive media coverage. 15 The presence of at least five symptoms in our study is 9.9% vs 4.3%, lower than the rate reported by the CLOCK study (23.7% vs 3.8%). The age differences in both studies can explain this.…”

Section: Open Accesscontrasting

confidence: 81%

“…However, the residual difference was only 0.8%, implicating a very low prevalence of long COVID in children attributable to the infection itself 14. These differences were addressed by Molteni herself and explained by some possible reasons: different study design, different response rates (and thus a better or worse representation of the entire paediatric population), gender imbalance, recall bias and the higher awareness for this syndrome due to extensive media coverage 15…”

Section: Discussionmentioning

confidence: 99%

“…Most long COVID symptoms in children with a history of SARS-CoV-2 infection were more prevalent in the older age group [12][13][14][15][16][17][18] compared with the younger age group, [5][6][7][8][9][10][11] including headaches (56 (25%) vs 155 (19%), p=0.05), weakness (60 (26.8%) vs 112 (13.7%), p<0.001), fatigue (64 (28.6%) vs 77 (9.4%), p<0.001), taste (32 (14.3%) vs 28 (3.4%), p<0.001), smell (36 (16.1%) vs 31 (3.8%), p<0.001), myalgia (34 (15.2%) vs 65 (8%), p=0.002), decreased mood (29 (12.9%) vs 40 (4.9%), p<0.001) and attention (30 (13.4%) vs 68 (8.3%), p=0.028). None of the symptoms were more prevalent in the younger age group (online supplemental material table 1S part B; figure 2).…”

Section: Long Covid Symptomsmentioning

confidence: 99%

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Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study

Adler

Israel²,

Yehoshua

et al. 2023

BMJ Open

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ObjectivesTo estimate the prevalence of long COVID symptoms in children with and without a history of SARS-CoV-2 infection and to evaluate factors associated with long COVID.DesignA nationwide cross-sectional study.SettingPrimary care.Participants3240 parents of children aged 5–18 with and without SARS-CoV-2 infection completed an online questionnaire (11.9% response rate); 1148 and 2092 with/without a history of infection, respectively.Primary and secondary outcome measuresPrimary outcome was the prevalence of long COVID symptoms in children with/without a history of infection. Secondary outcomes were the factors associated with the presence of long COVID symptoms and with failure to return to baseline health status in children with a history of infection including gender, age, time from illness, symptomatic illness and vaccine status.ResultsMost long COVID symptoms were more prevalent in children with a history of SARS-CoV-2 infection: headaches (211 (18.4%) vs 114 (5.4%), p<0.001), weakness (173 (15.1%) vs 70 (3.3%), p<0.001), fatigue (141 (12.3%) vs 133 (6.4%), p<0.001) and abdominal pain (109 (9.5%) vs 79 (3.8%), p<0.001). Most long COVID symptoms in children with a history of SARS-CoV-2 infection were more prevalent in the older age group (12–18) compared with the younger age group (5–11). Some symptoms were more prevalent in children without a history of SARS-CoV-2 infection, including attention problems with school malfunctioning (225 (10.8%) vs 98 (8.5%), p=0.05), stress (190 (9.1%) vs 65 (5.7%), p<0.001), social problems (164 (7.8%) vs 32 (2.8%)) and weight changes (143 (6.8%) vs 43 (3.7%), p<0.001).ConclusionThis study suggests that the prevalence of long COVID symptoms in children with a history of SARS-CoV-2 infection might be higher and more prevalent in adolescents than in young children. Some of the symptoms, mainly somatic symptoms, were more prevalent in children without a history of SARS-CoV-2 infection, highlighting the impact of the pandemic itself rather than the infection.

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Section: Open Accesscontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Long Covid Symptomsmentioning

confidence: 99%

See 1 more Smart Citation

Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study

Adler

Israel²,

Yehoshua

et al. 2023

BMJ Open

View full text Add to dashboard Cite

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“…As already anticipated, younger people are no strangers to the psychological and social burden that has resulted from COVID-19 pandemic. Recent studies investigating the long-term effect of COVID-19 on children and adolescents have surprisingly suggested that, for all outcomes related to the psychological and social sphere, young subjects who did not develop COVID-19 reported even more frequent problems than their counterparts who instead developed the disease [ 17 , 18 ]. However, the two extremes of life present substantial differences in terms of the needed psycho–social support.…”

Section: Psycho–social Impactmentioning

confidence: 99%

When the Pandemic Will Be Over: Lots of Hope and Some Concerns

et al. 2022

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The COVID-19 pandemic significantly threatened healthcare systems worldwide. The worst-hit population has been represented by older people with underlying chronic comorbidities, while children and adolescents developed mild or asymptomatic forms of the disease. However, certain medical conditions (i.e., obesity, respiratory, or neurological or immune disorders) may increase the risk for poor health outcomes even in young and middle-aged people. Beyond the direct negative effects of the infection, the pandemic posed several health challenges through an increase in psycho–social issues (i.e., anxiety, depression, fatigue, sleep alterations, loneliness, reduced assistance, and loss of income). Accordingly, the pandemic is negatively impacting the accumulation of the functional reserves of each individual, starting from early life. With the long-term effects of the pandemic to be seen in the coming years, clinicians must be prepared to manage such high clinical complexity of people they encounter, through the implementation of multidimensional and multidisciplinary interventions.

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“… 2 This approach has led to an unfruitful discussion focusing on whether PCCs are a real entity in children, or a psychological consequence of social restrictions. 3 In turn, such an approach risks hindering funds availability for the management and in‐depth biomolecular studies for the characterization of pediatric PCCs. As a consequence, families are struggling to find answers to their children's illnesses.…”

Section: Figurementioning

confidence: 99%

A call to invest in immunological determinants of pediatric post‐COVID conditions: Insights from a post‐COVID pANCA+ diffuse alveolar hemorrhage in an adolescent

Buonsenso

2022

Pediatric Pulmonology

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COVID p-ANCA vasculitis. [6][7][8] All together, these observations drive me to ask the whole scientific community to recognize that post-viral illness (and, therefore, PCCs), although less frequently than in adults, can impact on children as well. Only if the whole scientific community and major international journals recognize this problem, researchers involved in pediatric PCCs and families will have the possibility to access the needed resources for research, diagnostics, and treatments. Ultimately, this will help all the hidden and neglected children and young people that have suffered or are still suffering from uncharacterized postinfectious chronic diseases. 9

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Assessing the impact of the pandemic in children and adolescents: SARS-CoV-2 infection and beyond

Cited by 8 publications

References 8 publications

Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study

Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study

When the Pandemic Will Be Over: Lots of Hope and Some Concerns

A call to invest in immunological determinants of pediatric post‐COVID conditions: Insights from a post‐COVID pANCA+ diffuse alveolar hemorrhage in an adolescent

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