Although the Brazilian Amazon is still one of the most well-conserved environments in the world, it contains an extensive network of waterways that are used by a wide range of vessels that transport both people and cargo, as well as undertaking other activities. To plan environmental risk disaster strategies here, the potential effects of technological disasters, including marine accidents, must be taken into consideration. This paper seeks to redress this by providing a review of the possible risks to the Amazon aquatic environment that could result from various types of marine accidents. While the Amazon region has been researched worldwide, both extensively and intensively, regarding land use, climate, and environmental characterization, work in this field is scarce. A review of the main environmental characteristics of the Amazon is provided, including a description of common marine accidents that have occurred in this region. The environmental impacts experienced by the aquatic environment due to marine accidents worldwide were reviewed from the scientific literature to examine potential risks to the Amazon waterways. It was found that marine accidents, such as fire/explosions and the sinking of ships with different types of cargo, can cause the spillage of oil and other hazardous materials, causing catastrophic damage to the aquatic environment. Changes in the hydrological characteristics of rivers, including unexpected changes in the weather, such as heavy rain and winds, may also influence pollutant dispersion. Initiatives to deal with these technological hazards in the Amazon basin should also consider the potential social and environmental impacts in the protected areas of this region. It is hoped that this paper can serve as a starting point toward the governance and planning of risk disaster management actions, which are aimed at reducing the negative environmental impacts caused by marine accidents in the region.