Assessing the Intense Influenza A(H1N1)pdm09 Epidemic and Vaccine Effectiveness in the Post-COVID Season in the Russian Federation

Sominina, Anna; Danilenko, Daria; Komissarov, Andrey B.; Pisareva, Maria; Fadeev, Artem; Konovalova, Nadezhda; Eropkin, Mikhail; Petrova, Polina; Zheltukhina, Alyona; Musaeva, Tamila; Eder, Veronika; Ivanova, Anna; Komissarova, Kseniya; Stolyarov, Kirill; Karpova, Ludmila; Smorodintseva, Elizaveta; Dorosh, Anna; Krivitskaya, Vera; Kuznetzova, Elena; Majorova, Victoria; Petrova, Ekaterina; Boyarintseva, Anastassia; Ksenafontov, Andrey; Shtro, Anna; Nikolaeva, Julia; Bakaev, Mikhail; Burtseva, Elena; Lioznov, Dmitry

doi:10.3390/v15081780

Cited by 13 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the first days of February, it gave way to B/Victoria. Throughout the epidemic, A/H3N2 was lower than 1% of all influenza viruses, circulating in Russia [7].…”

Section: Resultsmentioning

confidence: 98%

Humoral Immunity to Influenza Infection among the Russian Population

Ilyicheva,

Ivanova,

Marchenko

2023

Preprint

View full text Add to dashboard Cite

This paper presents a study of human blood sera samples, collected in various regions of the Russian Federation, with regard to both vaccine and pandemic avian influenza viral strains. Just before the 2022-2023 epidemic season, herd immunity to seasonal influenza A viruses was reportedly lower than before the COVID-19 pandemic. Since no stable circulation of A/H5Nx and A/H9N2 influenza in the human population was observed during this period, we believe 100% vaccination against seasonal influenza is necessary for employees of poultry farms and other organizations, closely connected to the breeding and processing of poultry. In addition to protection against seasonal influenza, vaccination can hamper the emergence of new viral variants, driven by genome reassortment, during simultaneous infection of humans with seasonal human and animal influenza viruses.

show abstract

“…From the first days of February, it gave way to B/Victoria. Throughout the epidemic, A/H3N2 was lower than 1% of all influenza viruses, circulating in Russia [7].…”

Section: Resultsmentioning

confidence: 98%

Humoral Immunity to Influenza Infection among the Russian Population

Ilyicheva,

Ivanova,

Marchenko

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…This section addresses the results of the application of SIV, were vaccination campaign starts on October till February of next year (i.e.,  150 days or 21 weeks). The number of distributed doses in 2019/2020 season was 4,500,000 [61] with estimated vaccine efficacy (VE) up to 80.04% [62]. The estimated R0 was between 1.2-3.1 [63].…”

Section: Resultsmentioning

confidence: 99%

Strategic Optimization of Influenza Vaccine Allocation: A Case Study of Age-Specific Approaches in Saudi Arabia

Alkhamis,

Hosny

2024

Preprint

View full text Add to dashboard Cite

Acute lower respiratory tract infection is a major health problem that affects more than 15% of the total population of Saudi Arabia each year. Epidemiological studies conducted over the last three decades have indicated that viruses are responsible for the majority of these infections. The epidemiology of respiratory viruses in Saudi Arabia is believed to be affected mainly by the presence and mobility of large numbers of foreign workers and the gathering of millions of Muslims in Mecca during the Hajj and Umrah seasons. Knowledge concerning the epidemiology, circulation pattern, and evolutionary kinetics of respiratory viruses in Saudi Arabia are scant, with the available literature being inconsistent. After reviewing the available data on epidemiology and evolution of respiratory viruses, this study examines the effect of varying vaccination rates across different age groups during the 2019/2020 influenza season in Saudi Arabia. Utilizing an age-structured SEIR (Susceptible–Exposed–Infectious–Recovered) model, it develops customized vaccination policies by considering age-specific incidence rates. This pioneering research segments the population into five age groups—infants and school-aged children, junior and older youth, young adults and adults, middle-aged, and seniors—across five regional areas in Saudi Arabis: Eastern, Central, Northern, Western, and Southern. A contact matrix, compiled from multiple sources, is used to delineate the dynamics of influenza transmission. The study undertakes a thorough comparison of three distinct vaccination scenarios: no vaccination, national vaccination, and optimized vaccine allocation policy, under various potential pandemic situations. It examines their impact on vaccination campaigns in terms of the total number of infections, mortality, and morbidity rates. The results emphasize the crucial impact of population demographics on disease transmission and vaccine distribution. According to the findings, the optimized vaccination scenario proved to be the most effective strategy in all scenarios.

show abstract

“…Following an outbreak, the influenza virus has been seen to re-assort with various types of genetic alterations, creating a new strain that may further fuel an epidemic 13 . According to the World Health Organization, the H1N1pdm09 or H3N2 subtype of the influenza A virus has been co-circulating in the European region throughout the 2018–2019 flu season 14 . However, either influenza A(H1N1) pdm09 or A(H3N2) dominated (2014/15–2016/17) of influenza season 15 .…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of influenza virus circulating in Nepal in the year 2019

Mehta,

Jha,

Awal

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Influenza (sometimes referred to as “flu”) is a contagious viral infection of the airways in the lungs that affects a significant portion of the world's population. Clinical symptoms of influenza virus infections can range widely, from severe pneumonia to moderate or even asymptomatic sickness. If left untreated, influenza can have more severe effects on the heart, brain, and lungs than on the respiratory tract and can necessitate hospitalization. This study was aimed to investigate and characterize all types of influenza cases prevailing in Nepal and to analyze seasonal occurrence of Influenza in Nepal in the year 2019. A cross sectional, retrospective and descriptive study was carried out at National Influenza Center (NIC), National Public Health Laboratory Kathmandu Nepal for the period of one year (Jan–Dec 2019). A total of 3606 throat swab samples from various age groups and sexes were processed at the NIC. The specimens were primarily stored at 4 °C and processed using ABI 7500 RT PCR system for the identification of Influenza virus types and subtypes. Data accessed for research purpose were retrieved from National Influenza Centre (NIC) on 1st Jan 2020. Of the total 3606 patients suspected of having influenza infection, influenza viruses were isolated from 1213 (33.6%) patients with male predominance. The highest number of infection was caused by Influenza A/Pdm09 strain 739 (60.9%) followed by Influenza B 304 (25.1%) and Influenza A/H3 169 (13.9%) and most remarkable finding of this study was the detection of H5N1 in human which is the first ever case of such infection in human from Nepal. Similar to other tropical nations, influenza viruses were detected year-round in various geographical locations of Nepal. The influenza virus type and subtypes that were in circulation in Nepal were comparable to vaccine candidate viruses, which the currently available influenza vaccine may prevent.

show abstract

Assessing the Intense Influenza A(H1N1)pdm09 Epidemic and Vaccine Effectiveness in the Post-COVID Season in the Russian Federation

Cited by 13 publications

References 21 publications

Humoral Immunity to Influenza Infection among the Russian Population

Humoral Immunity to Influenza Infection among the Russian Population

Strategic Optimization of Influenza Vaccine Allocation: A Case Study of Age-Specific Approaches in Saudi Arabia

Molecular characterization of influenza virus circulating in Nepal in the year 2019

Contact Info

Product

Resources

About