To assess knowledge, attitudes, and practices of people toward coronavirus disease 2019 (COVID-19) pandemic in National Capital Territory of Delhi and National Capital Region (NCR), India. Various nations, including India, devised strategies to impose lockdowns and movement restrictions on their citizens in order to mitigate the effects of COVID-19. Cooperation and compliance by the populace are crucial to the effectiveness of such measures. People’s knowledge, attitudes, and behavior toward such diseases are crucial in determining the adaptability of a society to such changes. Using Google Forms, a self-designed semi-structured questionnaire was created. This study is cross-sectional. Participants were eligible to participate if they were over the age of 18 and presently resided in the study area. The questionnaire included demographic variables such as gender, age, location, occupation, and income level. A total of 1,002 people completed the survey. A 48.80% of the respondents in the study group were females. The mean knowledge score was 13.14 (Maximum Score = 17), while the mean attitude score was 27.24 (Maximum Score = 30). Most of the respondents (96%) had adequate knowledge about the disease’s symptoms. A 91% of the respondents had an average attitude score. A 74.85% of respondents accepted that they had avoided large social events. Gender had a negligible impact on the average knowledge score, while the score differed significantly across education levels and occupation categories. Consistent dissemination of messages regarding the virus, its spread, control measures implemented, and precautions expected from the public aids in reassuring the public and reducing their anxiety regarding the virus.