Assessing the levels interleukin-6, anti-cardiolipin antibodies, and selenium among hepatitis patients

Abstract

The pro-inflammatory interleukin-6 implicated in viral clearance and viral hepatic diseases. Selenium (Se) is an antioxidant trace element; serum selenium level is highly linked with liver disease severity. Aims of the paper were to investigate the anti-cardiolipin antibodies (IgG and IgM), systemic levels of interleukin-6 and selenium as well as to examine the relationships between these parameters in patients with chronic hepatitis B and C virus infections. From 50 with HCV and 38 with HBV and 30 healthy control age-matched individual's blood samples were collected. The sera levels of ACLA-IgG, ACLA-IgM, and IL-6 were determined by using enzyme-linked immune-sorbent assays. Flameless Atomic Absorption used for selenium measuring. Sera levels of ACLA-isotypes, IL-6 were significantly greater in patients groups, whereas the significantly low level of Se was observed in patients comparing to control. Regarding the comparison among patient groups, HCV patients exhibited respectable elevation in serum levels of IL-6 and Se, whereas no significant differences in ACLA iso-types level as compared to the HBV patients group. Additionally, the correlation between serum ACLA-isotypes and IL-6 showed positive correlations, serum selenium was inversely related to IL-6 and ACLAisotypes among hepatitis patients. The outcomes may show a role of IL-6 elevation and a selenium deficiency can be considered as a risk factor for viral hepatitis, related pathogenesis and progression of the disease. So testing sera selenium and IL-6 must be careful.