Assessing the magnetic resonance imaging in determining the depth of invasion of tongue cancer

Fu, Junjie; Zhu, Ling; Li, Jiang; Chen, Peiqian; Shi, Wentao; Shen, Shukun; Zhang, Chenping; Zhang, Zhiyuan

doi:10.1111/odi.13579

Cited by 21 publications

(19 citation statements)

References 26 publications

(29 reference statements)

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“…In this study, four kinds of MR sequences were applied in the measurement of DOI. We found significant correlation between MRI-derived DOI on each sequence and pathological DOI, the partial results of which are consistent with previous studies [11,13,17]. Although correlations are interesting, a factor warranting greater attention is that MRI-derived DOI was significantly larger than histopathological DOI, which led to the overestimating of T stages [12,13].…”

Section: Discussionsupporting

confidence: 89%

“…However, there was disagreement on avoiding this factor, which mainly focused on the choice of MR sequence. Some researchers thought that T2WI was better for measurement than T1WI [9,18]; others had the opposite view [13]. Baba et al [16] reported that the measurement of CE-T1WI-derived DOI was slightly more accurate than that of T2WI-derived DOI for a better correlation between CE-T1WI-derived DOI and histopathological DOI.…”

Section: Discussionmentioning

confidence: 99%

“…Due to its excellent soft tissue resolution, magnetic resonance imaging (MRI) is widely applied in the assessment of clinical DOI of OTSCC [9][10][11][12][13][14][15][16][17]. However, MRI-derived DOI was statistically larger than histopathological DOI [9,[13][14][15] due to peritumor edema or inflammation, which might lead to overestimated clinical T staging. Consensus has not been reached on which MRI sequence was suitable for DOI measurement.…”

Section: Introductionmentioning

confidence: 99%

“…Consensus has not been reached on which MRI sequence was suitable for DOI measurement. Some researchers suggested that the T2-weighted imaging (T2WI) was better for the measurements of DOI [9,18], while others performed the measurement on contrast enhanced T1WI (CE-T1WI) [11][12][13]. Moreover, with the rapid development of technologies, MRI sequences such as dynamic contrast-enhanced sequences or diffusion-weighted imaging (DWI) were applied [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of tumor depth in oral tongue squamous cell carcinoma with multiparametric MRI: correlation with pathology

et al. 2021

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Objectives To compare the correlation of depth of invasion (DOI) measured on multiple magnetic resonance imaging (MRI) sequences and pathological DOI, in order to determine the optimal MRI sequence for measurement. Methods A total of 122 oral tongue squamous cell carcinoma (OTSCC) patients were retrospectively analyzed, who had received preoperative MRI and surgical resection. DOIs measured on fat-suppressed T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), dynamic enhanced-T1 high-resolution insotropic volume examination (e-THRIVE), and contrast-enhanced fat-suppressed T1WI (CE-T1WI) were respectively compared to those measured in pathologic specimens. The cutoff value of the best correlated MRI sequence was determined, and the T staging accuracy of MRI-derived DOI was evaluated. Results DOI derived from e-THRIVE showed the best correlation (r = 0.936, p < 0.001) with pathological DOI. The area under the curve values of MRI-derived DOI distinguishing T1 stage from T2 stage and distinguishing T2 stage from T3 stage were 0.969 and 0.974, respectively. The T staging criteria of MRI-derived DOI were 6.2 mm and 11.4 mm, with a staging accuracy of 86.9% compared to pathological DOI criteria of 5 mm and 10 mm. Conclusion E-THRIVE was the optimal MR sequence to measure the MR-derived DOI, and DOI derived from e-THRIVE could serve as a potential cut-off value as a clinical T staging indicator of OTSCC. Key Points • Multiparametric MRI helps radiologists to assess the neoplasm invasion in patients with oral tongue squamous cell carcinoma. • Retrospective study indicated that measurement was most accurate on enhanced-T1 high-resolution insotropic volume examination dynamic contrast enhancement images. • T staging of oral tongue squamous cell carcinoma was accurate according to the dynamic contrast enhancement MRI-derived depth of invasion.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of tumor depth in oral tongue squamous cell carcinoma with multiparametric MRI: correlation with pathology

et al. 2021

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“…Although the UICC and AJCC state that ultrasonography is not suitable for the evaluation of primary lesions [9], some studies have evaluated primary lesions with intraoral ultrasonography (US) and have shown a strong correlation with histopathological thickness or DOI [10][11][12][13]. To date, several reports have been made on CT, MRI, and US preoperative radiological DOI evaluations, but there is no report of a study where these were all performed in a single institution [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Therefore, this study was aimed to investigate the accuracy of preoperative radiological DOI measurement with CT, MRI, and US in the same target group based on histopathologically measured DOI for T1 and T2 tongue cancers, where a diagnosis of DOI around 5 mm is an important diagnostic finding and examine the effectiveness of each imaging modalities with retrospective approach.…”

Section: Introductionmentioning

confidence: 99%

A comparative study between CT, MRI, and intraoral US for the evaluation of the depth of invasion in early stage (T1/T2) tongue squamous cell carcinoma

et al. 2021

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Objectives This study aimed to clarify the accuracy of intraoral ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) in preoperative image depth of invasion (DOI) measurement of T1/T2 tongue cancer through comparison with histopathological measurements. Methods Imaging of the primary lesions was performed at our hospital; the lesions were classified into T1 and T2 based on the 8th edition of the AJCC/UICC, and surgery performed. There was histopathological confirmation of lesions as squamous cell carcinoma in 48 patients with tongue cancer. T3 and T4 cases, cases in which preoperative chemotherapy and radiation therapy were performed, and cases where biopsy was performed before imaging were excluded. The radiological DOI in US, CT, and MRI and the histopathological DOI as base were comparatively investigated and statistical analyses were performed by Bland–Altman analysis and Spearman's rank correlation coefficient. Results Bland–Altman analysis showed that the US radiological DOI was overestimated by an average of 0.2 mm compared to the histopathological DOI, while CT and MRI radiological DOI were overestimated by an average of 2–3 mm. The comparison of CT and MRI revealed that the difference between the MRI and histopathological DOI, as well as the 95% limit of agreement, were smaller than those of the CT radiological DOI. Conclusions US is the most accurate preoperative diagnostic tool for T1 and T2 squamous cell carcinoma; CT and MRI tend to have an overestimation of about 2–3 mm and so caution is required.

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Ultrasound accurately assesses depth of invasion in T1‐T2 oral tongue cancer

Nilsson

Knutsson

Landström

et al. 2022

Laryngoscope Investig Oto

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Background Depth of invasion (DOI) is important for the T‐classification of squamous cell carcinoma of the oral tongue (SCCOT) and incorporated in the TNM 8 classification of oral cavity cancer. To determine DOI clinical palpation is performed, but the preferred radiological modality remains controversial. The aim of this study was to investigate the assessment of DOI using ultrasound (US‐DOI). Methods The DOI was assessed in 40 patients with T1–T3 SCCOT by ultrasound, palpation, computed tomography and magnetic resonance imaging (MRI). Histopathological DOI (H‐DOI) was gold standard. Bland–Altman analysis was used to compare mean difference and 95% limits of agreement (LOA). Results The mean difference of US‐DOI was −0.5 mm (95% LOA −4.9–4.0) compared to H‐DOI and the mean difference for MRI was 3.9 mm (95% LOA −2.3–10.2). In the subgroup analysis of cT1‐T2 the US‐DOI mean difference was 0.1 mm and the 95% LOA limits −2.5–2.7. Conclusions Ultrasound seems to be the most accurate method to assess DOI in T1‐T2 SCCOT. MRI overestimates DOI and cannot assess a substantial proportion of the tumors. Level of Evidence 2c.

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Assessing the magnetic resonance imaging in determining the depth of invasion of tongue cancer

Cited by 21 publications

References 26 publications

Assessment of tumor depth in oral tongue squamous cell carcinoma with multiparametric MRI: correlation with pathology

Assessment of tumor depth in oral tongue squamous cell carcinoma with multiparametric MRI: correlation with pathology

A comparative study between CT, MRI, and intraoral US for the evaluation of the depth of invasion in early stage (T1/T2) tongue squamous cell carcinoma

Ultrasound accurately assesses depth of invasion in T1‐T2 oral tongue cancer

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