Assessing the Performance of a Novel Stool-Based Microbiome Test That Predicts Response to First Line Immune Checkpoint Inhibitors in Multiple Cancer Types

Robinson, I.; Hochmair, Maximilian; Schmidinger, Manuela; Absenger, Gudrun; Pichler, Martin; Nguyen, Van Anh; Richtig, Erika; Rainer, Barbara M.; Ay, Leyla; Jansen, Christian; Pacífico, Cátia; Knabl, Alexander; Sladek, Barbara; Gasche, Nikolaus; Valipour, Arschang

doi:10.3390/cancers15133268

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…At the genus level, the abundance of Lachnospiraceae was significantly lower in male mice than in females, whereas the converse was true for the Muribaculaceae family [96,97]. Lachnospiraceae has been linked to immune checkpoint inhibitor responses [98], whereas Muribaculaceae plays a key role in AOM/DSS-induced CRC [99]. These findings underscore the potential significance of sex hormones as targets for enhancing the antitumor efficacy of anti-PD-L1.…”

Section: Microgenderome-based Therapeutic Approachesmentioning

confidence: 89%

Sex differences in colorectal cancer: with a focus on sex hormone–gut microbiome axis

Wu,

Huang,

Zhang

et al. 2024

Cell Commun Signal

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Sexual dimorphism has been observed in the incidence and prognosis of colorectal cancer (CRC), with men generally exhibiting a slightly higher incidence than women. Research suggests that this difference may be attributed to variations in sex steroid hormone levels and the gut microbiome. The gut microbiome in CRC shows variations in composition and function between the sexes, leading to the concept of ‘microgenderome’ and ‘sex hormone–gut microbiome axis.’ Conventional research indicates that estrogens, by promoting a more favorable gut microbiota, may reduce the risk of CRC. Conversely, androgens may have a direct pro-tumorigenic effect by increasing the proportion of opportunistic pathogens. The gut microbiota may also influence sex hormone levels by expressing specific enzymes or directly affecting gonadal function. However, this area remains controversial. This review aims to explore the differences in sex hormone in CRC incidence, the phenomenon of sexual dimorphism within the gut microbiome, and the intricate interplay of the sex hormone–gut microbiome axis in CRC. The objective is to gain a better understanding of these interactions and their potential clinical implications, as well as to introduce innovative approaches to CRC treatment. Graphical Abstract

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Section: Microgenderome-based Therapeutic Approachesmentioning

confidence: 89%

Sex differences in colorectal cancer: with a focus on sex hormone–gut microbiome axis

Wu,

Huang,

Zhang

et al. 2024

Cell Commun Signal

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“…The bidirectional relationship between stress, the hypothalamus-pituitary-adrenocortical axis, and the gut microbiome involves Clostridium species, potentially influencing overall well-being and distress 50 . Furthermore, emerging research suggests that Clostridiaceae bacteria may impact breast cancer outcomes by interacting with the immune system, highlighting their relevance in the context of cancer treatment and quality of life for survivors 51 .These findings suggest that the microbiome may play an important role in the development of distress and impacts of LOQ of newly diagnosed breast cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Unraveling the connections between gut microbiota, stress, and quality of life for holistic care in newly diagnosed breast cancer patients

Lee,

Yang,

Liu

et al. 2023

Sci Rep

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There is little research about the stress, quality of life (QOL) and gut microbiota in newly diagnosed breast cancer patients. In this study addressing the dearth of research on stress, quality of life (QOL), and gut microbiota in newly diagnosed breast cancer patients, 82 individuals were prospectively observed. Utilizing the Functional Assessment of Chronic Illness Therapy (FACT)-Breast questionnaire to assess health-related quality of life (HRQOL) and the Distress Thermometer (DT) to gauge distress levels, the findings revealed a mean FACT-B score of 104.5, underscoring HRQOL's varied impact. Significantly, 53.7% reported moderate to severe distress, with a mean DT score of 4.43. Further exploration uncovered compelling links between distress levels, FACT-B domains, and microbial composition. Notably, Alcaligenaceae and Sutterella were more abundant in individuals with higher DT scores at the family and genus levels (p = 0.017), while Streptococcaceae at the family level and Streptococcus at the genus level were prevalent in those with lower DT scores (p = 0.028 and p = 0.023, respectively). This study illuminates the intricate interplay of stress, QOL, and gut microbiota in newly diagnosed breast cancer patients, offering valuable insights for potential interventions of biomarker or probiotics aimed at alleviating stress and enhancing QOL in this patient cohort.

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A two-step, two-sample Mendelian randomization analysis investigating the interplay between gut microbiota, immune cells, and melanoma skin cancer

Lou,

Xiang,

Zhu

et al. 2024

Medicine

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This study aims to rigorously explore the potential causal relationships among gut microbiota (GM), immune cells, and melanoma skin cancer among participants from Europe, where this disease exhibits significant prevalence and profound societal impact. Using the genome-wide association analysis database, a double-sample Mendelian randomization (MR) analysis was drawn upon to investigate GM, immune cells, and melanoma skin cancer. The inverse variance weighted approach was applied to estimate the causal connections among these variables. A two-step MR analysis was employed to quantitatively gauge the impact of immune cells mediated GM on melanoma skin cancer. To address potential sources of bias, such as pleiotropy and heterogeneity, multiple analytical techniques were integrated. The MR analysis pinpointed 6 GM taxa related to either an augmented or declined risk of late-stage melanoma skin cancer. In the same vein, 32 immune cell phenotypes were noticed as correlates with modified risk of melanoma skin cancer. Our study also implies that the probable association between GM and melanoma could be facilitated by 5 immune cell phenotypes. The findings of our study underline certain GM taxa and immune cells as potential influencers on the onset and development of melanoma skin cancer. Importantly, our results spotlight 5 immune cell phenotypes as potential agents mediating this association.

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Assessing the Performance of a Novel Stool-Based Microbiome Test That Predicts Response to First Line Immune Checkpoint Inhibitors in Multiple Cancer Types

Cited by 4 publications

References 33 publications

Sex differences in colorectal cancer: with a focus on sex hormone–gut microbiome axis

Sex differences in colorectal cancer: with a focus on sex hormone–gut microbiome axis

Unraveling the connections between gut microbiota, stress, and quality of life for holistic care in newly diagnosed breast cancer patients

A two-step, two-sample Mendelian randomization analysis investigating the interplay between gut microbiota, immune cells, and melanoma skin cancer

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