Assessing the pharmacological and biochemical effects of Salvia hispanica (Chia seed) against oxidized Helianthus annuus (sunflower) oil in selected animals

Abstract

Oil oxidation is important in terms of taste, nutritive component quality and toxic effect of the oil. In this study, the oxidized sunflower oil was used along with chia seed in rabbits for the determination of its effects on various hematological and serum biochemical parameters as well as on liver histopathology. Three rabbits were fed with oxidized oil (obtained by heating) at the dose rate of 2 ml/kg body weight by mixing it with green fodder. The other rabbit groups were fed with Chia seed at dose rate of 1, 2 and 3 g/kg along with oxidized sunflower oil. Chia seed was fed alone to three rabbits at the dose rate of 2 g/kg body weight. All rabbits were fed regularly for twenty-one days. For the determination of hematological and biochemical parameters, whole blood and serum samples were collected on different days during feeding period. For histopathology, liver samples were used. Significant changes (p<0.05) were noted in the hematology and biochemical indices in the rabbits that were fed with oxidized sunflower oil alone, and along with different doses of Chia seed. In a dose-dependent manner, all these parameters were significantly improved (p<0.05), when the amount of Chia seed was increased. The biochemical and hematological indices were in normal range in the group fed only with Chia seed. In oxidized oil fed group, liver histopathological analysis showed that cholestasis was present at both sides (bile pigment secretion) and zone 3 necrosis with mild inflammatory cells. Mild vacuolization of hepatocytes was also observed. In Chia seed fed group, hepatocyte vacuolization and mild necrosis was noted. It was concluded that oxidized sunflower oil alters the biochemical and hematological parameters and causes liver abnormalities. Chia seeds act as an antioxidant and retrieve those alterations.

In-Vivo AND In-Silico ANALYSIS OF ANTI- INFLAMMATORY, ANALGESIC, AND ANTI PYRETIC ACTIVITIES OF In-Silico LEAF EXTRACT

“…Therefore, the binding energy of standard drug was also higher than the C. paradisi leaf components such as geraniol and betapinene. The protein TRPV4 is selected as analgesic protein and it is confirmed by previous literature (22,(47)(48)(49)(50)(51)(52)(53). The docking of TRPV4 was done with 2 ligand molecules (geraniol and beta-pinene) and diclofenac is used as standard drug.…”

The Techno-Functionality of Chia Seed and Its Fractions as Ingredients for Meat Analogs

“…Salvia hispanica L., also known as chia, is a herbaceous plant belonging to the Plantae kingdom, Lamiaceae family, Salvia genus, and Hispanic species [ 25 ]. This seed is grown commercially in Mexico, Guatemala, Bolivia, Australia, Peru, Argentina, America, and Europe [ 26 , 27 ]. Of the 900 seed species of the Lamiaceae family, 61 are commercially cultivated in Brazil [ 28 ].…”

Evaluation of analgesic, antioxidant, and anti-inflammatory potential of Dianthus crinitus using mice as a research animal

“…Moreover, 25% of the ingredients used in pharmaceuticals are derived from medicinal plants (Robbers et al, 1996). Several studies have demonstrated that herbal medicines Evaluation of therapeutic potential of Dianthus crinitus using mice as a research animal from the Vedic era have been used for treating various disorders, such as heart diseases, cancer, digestive system diseases, central nervous system (CNS) diseases, diabetes, and inflammatory diseases (Ahmad et al, 2023a;Aqib et al, 2023;Ayesha et al, 2022;Aziz et al, 2023;Ejaz et al, 2023;Hussain et al, 2023;Naveed et al, 2022;Nureen et al, 2023;Rauf et al, 2023;Zawar et al, 2023).…”