Assessing the presence of pharmaceuticals in soil and plants irrigated with treated wastewater in Oman

Al-Farsi, Raya; Ahmed, Mushtaque; Al-Busaidi, Ahmed; Choudri, B. S.

doi:10.1007/s40093-018-0202-1

Cited by 30 publications

(16 citation statements)

References 34 publications

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“…However, it is also important to mention that our preliminary experiments, performed with ibuprofen concentrations closer to the reported values, yielded degraded products similar to those found with higher concentrations of ibuprofen. Moreover, these primary and degraded products are expected to further accumulate in the water bodies via biotic and abiotic mechanisms, resulting in higher concentrations yet (Al-Farsi et al, 2018;Muir et al, 2017). Thus, the implications discussed in this work are transferable to the environmentallyrelevant conditions.…”

Section: Toxicological Studiesmentioning

confidence: 92%

A toxicological study on photo-degradation products of environmental ibuprofen: Ecological and human health implications

Ellepola

Ogas

Turner

et al. 2020

Ecotoxicology and Environmental Safety

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Increasing quantities of pharmaceutical waste in the environment have disrupted the balance of ecosystems, and may have subsequent effects on human health. Although a handful of previous studies have shown the impacts of pharmaceutically active compounds on the environment, the toxicological effects of their degradation products remain largely unknown. In the current study, the photo-degradation products of environmental ibuprofen were assessed for both ecotoxicological and human health effects using a series of in vitro assays. Here, six of the major degradation products are synthesized with high purity (>98 %) and characterized with 1 HNMR, 13 CNMR, FT-IR and HRMS. To evaluate human health effects, three gut microbiota species, Lactobacillus acidophilus, Enterococcus faecalis and Escherichia coli, and two human cell lines, HEK293T and HepG2, are exposed to various concentrations of ibuprofen and its degradation products. On L. acidophilus, the ibuprofen degradation product (±)-(2R,3R)-2-(4isobutylphenyl)-5-methylhexan-3-ol shows a greater toxic effect while ibuprofen enhances its growth at lower concentrations. At higher concentrations, ibuprofen shows at least a 2-fold higher toxicity compared to that of its degradation products. However, E. faecalis shows little or no effect upon exposure to these compounds. An induction of the SOS response in E. coli is observed but limited to only ibuprofen and 4-acetylbenzoic acid. In human cell line studies, survival of both HEK293T and HepG2 cell lines is profoundly impaired by the photo-degradation products of (±)-(2R,3R)-2-(4-isobutylphenyl)-5-methylhexan-3-ol, (±)-(2R,3S)-2-(4-isobutylphenyl)-5methylhexan-3-ol, and (±)-1-(4-(1-hydroxy-2methylpropyl)phenyl)ethan-1-one. In this work, the bioluminescence bacterium, Aliivibrio fischeri, is used as a model to assess environmental impact.Both ibuprofen and its degradation products inhibit the growth of this gram-negative bacteria with the primary compound showing the most significant impact. Overall, our results highlight that *

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Section: Toxicological Studiesmentioning

confidence: 92%

A toxicological study on photo-degradation products of environmental ibuprofen: Ecological and human health implications

Ellepola

Ogas

Turner

et al. 2020

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

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“…In addition, the OM content generally increases the absorption of antibiotics because of the interaction between the organic groups (carboxyl and phenolic groups), ion exchange, and hydrogen bonding of the substrate matrix with the polar groups of the antibiotics. Therefore, substrates with high OM content, such as compost, soils, and compost/ soil mixtures, have been applied to remove tetracyclines, sulfonamides, salinomycin, quinolones, and tylosin (Al-Farsi et al, 2018;Carvalho and Santos, 2016;. There are many mechanisms involved in the wetlands system.…”

Section: Removal Of Antibiotics From Water By Constructed Wetlandsmentioning

confidence: 99%

“…The reuse of treated wastewater effluent for irrigation is a common practice in several countries especially not developed countries. Certainly, the reuse of treated wastewater effluent contaminated with multiple antibiotic-resistant bacteria will also reach in crops field and this could harm the end-user of these vegetables or fruits (Al-Bahry et al, 2012;Al-Farsi et al, 2018). Reuse of treated wastewater effluent for agriculture growth generally reaches the crops through root uptake.…”

Section: The Risk-on Humans and Risk Managementmentioning

confidence: 99%

Removal efficiency of antibiotics from water through constructed wetlands, a review

2021

Global NEST: The International Journal

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<p>Contamination in water bodies with antibiotics and resistance genes is becoming an increasing threat to global health. Overuse of antibiotics has become a serious ecological problem worldwide. There is growing concern that antibiotics are losing their effectiveness due to increased antibiotic resistance in bacteria. During the last twenty years, the consumption of antibiotics has increased rapidly, which has been cited as one of the world’s worst abusers of antibiotics. Several studies have been conducted to solve this issue. Developed countries have introduced several methods but constructed wetlands have been found low cost technology. Although constructed wetlands (CWs) offer a potential way to remove these antibiotics from water supplies, knowledge of their mechanisms is limited. In this review, we highlight important aspects of antibiotic pollution in waters, the removal efficiency of constructed wetlands for antibiotic removal and that antibiotic pollution affects many things which taken together poses several challenges for environmental scientists. It has been discovered that four main factors are affecting the performance of constructed wetlands used for the treatment of antibiotics in water supplies, the types configurations of constructed wetlands, hydraulic load rates, substrates, plants, and microorganisms. Further researches focusing on these factors are recommended to improve the removal efficiency of antibiotics in constructed wetlands. Outcomes of the study could help wastewater treatment plant engineers with providing reliable design data and outline a road map for future researches.</p>

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“…A considerable amount of research has been performed in Oman on various issues related to wastewater. Wastewater research focused on growing crops, impacts on soil, aquifer recharge using treated wastewater and other relevant issues (Al-Khamisi et al 2016a, b;Al-Busaidi and Ahmed 2014;Abdel Rahman et al 2011;Abdul Khaliq et al 2017a;Al-Farsi et al 2018), whereas sludge produced as by-product of wastewater treatment was investigated for its quality and likely use in crop production and remediation of contaminated sites (Al-Busaidi et al 2015;Padmavathiamma et al 2014;Al-Busaidi 2014).…”

Section: Reuse Of Wastewater Effluent In Omanmentioning

confidence: 99%

“…The reuse of treated wastewater effluent for irrigation is a common practice in many countries; it is certain that the reuse of treated wastewater effluent contaminated with multiple antibiotic-resistant bacteria would also reach the watered crop; this could harm the end user of these vegetables or fruits (Al-Bahry et al 2009;Al-Farsi et al 2018). The use of treated wastewater effluent as a reuse in agriculture and crop growing has shown to reach the crops through root uptake.…”

Section: The Risk On Humans and Risk Managementmentioning

confidence: 99%

Antibiotics in wastewaters: a review with focus on Oman

et al. 2018

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The occurrence of antibiotics in treated wastewater effluent has been a concern worldwide for various reasons: most importantly development of antibiotics resistance by bacteria and other microorganism, impact of antibiotics on animal life in surface water and likely consequences on humans if treated wastewater is used for drinking water supply through the process of managed aquifer recharge (MAR). Another potential area of concern is the uptake of these antibiotics by crops irrigated by treated wastewater. In Oman, wastewater treatment and reuse is pursued vigorously as a government policy. Treated wastewater is used for crop irrigation following government regulations, MAR is being contemplated and practiced in small scale and release of such waters in the ocean takes place from time to time. Some tests have been conducted on the wastewater effluent around the world to verify and detect the concentration of antibiotics in wastewater effluent. In the Sultanate of Oman, very little research has been performed on the occurrence of antibiotics in treated wastewater, removal efficiencies of treatment processes and development of antibiotics resistance. It is expected that wastewater reuse will increase substantially due to expansion of sewerage network in the capital city as well as many other cities and towns. As such, it is imperative that research be undertaken to find out various issues related to commonly used antibiotics such as ciprofloxacin, norfloxacin, erythromycin, linezolid, penicillin, ampicillin, chloramphenicol, streptomycin, minocycline, tetracycline and sulfamethoxazole in Oman and their ultimate fate through the treatment process. In addition, the development of guidelines is crucial in amounts of antibiotics acceptably occurring in treated wastewater effluent and if they could be suitable for agriculture without causing any harm. A review of the available literature and data are provided in this article. Research needs have been identified.

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Assessing the presence of pharmaceuticals in soil and plants irrigated with treated wastewater in Oman

Cited by 30 publications

References 34 publications

A toxicological study on photo-degradation products of environmental ibuprofen: Ecological and human health implications

A toxicological study on photo-degradation products of environmental ibuprofen: Ecological and human health implications

Removal efficiency of antibiotics from water through constructed wetlands, a review

Antibiotics in wastewaters: a review with focus on Oman

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