Assessing the prognostic factors, survival, and recurrence incidence of triple negative breast cancer patients, a single center study in Iran

Abstract

BackgroundBreast cancer is the second leading cause of death due to cancer in women. Triple negative breast cancer (TNBC) is a subgroup with unique behavior. There is a controversy in organ involvement in metastasis. In this study, we planned to define the prognostic factors, survival, and recurrence incidence of patients.Materials and methodAmong the 583 patients with breast mass referred to hematology and oncology clinic in Shariati hospital, Tehran, Iran from March 2005 to March 2015, fifty four patients entered the survival analysis whom we followed for two years until March 2017. Overall survival (OS) and disease-free survival (DFS) and Cumulative recurrence incidences (RI) were estimated. Univariate and multivariate Cox proportional hazards regression was performed to assess risk factors in predicting OS and DFS.ResultsMedian follow up for the patients was 5.00 years. The five-year OS, DFS and RI were 86.13% (95% CI (71.42–93.59), 63.09% (95% CI (47.04–75.49) and 32.15% (95% CI (19.52–47.43) respectively. Among the factors studied OS, DFS and RI differed significantly only between patients with and without nodal involvement (P = 0.004, P = 0.003, and P = 0.02 respectively). On the other hand, based on the univariate modeling, patients with nodal involvement had a higher risk of breast cancer-specific death (HR: 17.99, P = 0.004). Furthermore, patients with nodal involvement had a higher risk of breast cancer-specific death or recurrence (HR = 5.64, P = 0.008). In Multivariate model, just the nodal involvement significantly changed the hazard for OS (HR = 23.91, P = 0.001). As the nodal involvement was the only significant risk factor at the 0.2 level of significance, we can consider the hazard ratio of lymph node positivity in DFS univariate models as adjusted hazard.ConclusionThe only factor with significant effect on OS, DFS and RI was nodal involvement in the pathology report.

Clinicopathological Characteristics and Survival of Triple-Negative Breast Cancer Patients: A single Institution Study from Egypt

“…The 5-year OS rate in our study was 88% which is comparable to that reported by a study from China where the 5-year OS rate was 88.5% 17 , and another study from Iran where the 5-year survival was 86.1% 18 . On the other hand, the 5-year OS rates were much lower in other studies.…”

Radiomic differentiation of breast cancer molecular subtypes using pre-operative breast imaging – A systematic review and meta-analysis

“…The plausibility of diagnostic MMG to inform such crucial clinical details is encouraging, having the potential to fast-track treatment decision making in clinical practice. This is particularly prudent for TNBC, and the inherent threat and aggressive natural history of TNBC is irrefutable in surgical and medicooncological literature [65]. MMG remains the standard diagnostic tool in worldwide breast cancer screening programmes, with screening mammography performed 38 million times per annum in the United States according to the Mammography Quality Standards Act and Program [66], as well as diagnostic sensitivity and specificity rates in excess of 85% [67].…”

Prognostic factors in triple-negative breast cancer: a retrospective cohort

“…In a study of 583 patients, Mousavi et al 24 demonstrated that lymph node involvement was the only prognostic factor related to decreased DFS in TNBC. However, other studies have demonstrated that a larger tumor size and residual tumor burden correlate with a higher recurrence risk and lower DFS in TNBC 25 .…”