Assessing the risk factors for anxiety, depression and post‐traumatic stress disorder through the International Pemphigus and Pemphigoid Foundation

Patel, Payal M.; Jones, Virginia; Kridin, Khalaf; Strong, R; Amber, Kyle T.

doi:10.1111/jdv.17700

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…A recent study led by the University of Illinois at Chicago and the International Pemphigus & Pemphigoid Foundation suggested that younger age and systemic corticosteroid therapy are significant predictors for depression and anxiety in pemphigus patients. 23 Other studies have shown controversial results for age and emphasized instea female sex, clinical disease activity in the past, number of days spent as a dermatology inpatient, and shorter clinical remission on the day of assessment. 11,14 In our study, we identified risk factors including autoimmune thyroiditis comorbidity, disease-related hospitalization history, and active mucosal involvement, while age, sex, obesity, disease stage and severity, and corticosteroid use were unexpectedly not associated with anxiety or depressive disorders.…”

Section: Discussionmentioning

confidence: 99%

“…We further explored the relevant clinicodemographic parameters for mood disorders in pemphigus. A recent study led by the University of Illinois at Chicago and the International Pemphigus & Pemphigoid Foundation suggested that younger age and systemic corticosteroid therapy are significant predictors for depression and anxiety in pemphigus patients 23 . Other studies have shown controversial results for age and emphasized instea female sex, clinical disease activity in the past, number of days spent as a dermatology inpatient, and shorter clinical remission on the day of assessment 11,14 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Psychological morbidity in patients with pemphigus and its clinicodemographic risk factor: A comparative study

Wang

Hai-xi

Cong

et al. 2023

The Journal of Dermatology

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Due to the long disease duration, impact on appearance, social stigmatization, and numerous side effects of treatment, pemphigus, an autoimmune bullous disease, often has a significant psychological impact on patients. On the other hand, mood disorders may exacerbate the disease by affecting the patient's self‐management, forming a vicious circle. To investigate anxiety and depressive disorders in patients with pemphigus, a total of 140 patients with pemphigus were recruited for this cross‐sectional retrospective study between March 2020 and January 2022. A control group of 118 patients with psoriasis, a commonly known psychosomatic dermatosis, was established. Patients were evaluated at the visiting day with the Beck Anxiety Inventory and Beck Depression Inventory second edition for mood disorders, the Dermatology Life Quality Index and the EuroQol Five Dimensions Questionnaire for disease‐related life quality, and the Visual Analogue Scale for pain and itching symptoms. In our cohort, 30.7% of patients with pemphigus suffered from either anxiety disorder (25%) or depressive disorders (14.3%). Propensity score matching was implemented to create a comparable cohort of pemphigus and psoriasis groups considering the baseline discrepancy. Thirty‐four comparable pairs of pemphigus and psoriasis patients were extracted. The prevalence and severity of depressive disorder in pemphigus patients were significantly higher than in psoriasis patients, while anxiety disorder levels appeared to be similar in two groups. Multivariate logistic regression analysis further revealed that disease‐related hospitalization history, active mucosal damage, and concomitant thyroid disease are independent risk factors for mood disorders in pemphigus patients. Our results showed that pemphigus patients had a high prevalence and severity of mood disorders. Relevant clinicodemographic indicators may be valuable for prediction and early identification of mood disorders in pemphigus. Better disease education from physicians may be important for these patients to achieve overall disease management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Psychological morbidity in patients with pemphigus and its clinicodemographic risk factor: A comparative study

Wang

Hai-xi

Cong

et al. 2023

The Journal of Dermatology

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“…However, continuing evidence has indicated that dry eye is significantly associated with poor quality of life, anxiety, depression, psychiatric symptoms and impaired sleep quality, which also shows a high prevalence in patients with AIBD and leads to serious deleterious effects on quality of life [ 29 , 30 ]. To date, only a few studies have measured subjective well-being in patients with AIBD, and no study has focused on poorer quality of life related to dry eye in patients with AIBD.…”

Section: Discussionmentioning

confidence: 99%

“…The scores are calculated using the following formula: OSDI = (sum of scores for all questions answered × 100)/ (total number of questions answered × 4). Higher scores indicate more severe conditions, and the overall OSDI scores define the ocular surface as normal (0-12), mild (13)(14)(15)(16)(17)(18)(19)(20)(21)(22), moderate (23)(24)(25)(26)(27)(28)(29)(30)(31)(32) or severe (above 33) [17].…”

Section: Questionnairesmentioning

confidence: 99%

Ocular surface disorders affect quality of life in patients with autoimmune blistering skin diseases: a cross-sectional study

Kang

Feng

et al. 2022

BMC Ophthalmol

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Background Autoimmune blistering skin diseases (AIBD) are a group of rare chronic autoimmune diseases which are associated with ocular surface diseases especially dry eye disease. This study is designed to investigate the relationship between ocular surface disorders and quality of life among patients with autoimmune blistering skin diseases. Methods Twenty-four AIBD patients (18 pemphigus and 7 pemphigoid) and twenty-five non-AIBD controls were included. Ocular surface disease index (OSDI), ocular surface evaluation, including slit-lamp examination, Schirmer I test, tear break-up time, corneal fluorescein staining, lid-parallel conjunctival folds, meibomian gland evaluation, presence of symblepharon and corneal opacity were assessed. Life quality was evaluated by multiple questionnaires, including Medical Outcomes Study 36-Item Short Form Questionnaire (SF-36), Hospital Anxiety and Depression Scale (HADS), Pittsburgh Sleep Quality Index (PSQI) and Health Assessment Questionnaire-Disability Index (HAQ-DI). Ocular surface tests and quality of life were compared between AIBD patients and non-AIBD controls. In the AIBD patients, the associations between ocular surface parameters and quality of life were also evaluated. Results 92% of AIBD patients and 87.5% of age- and sex-matched non-AIBD controls were diagnosed with dry eye in this study. Compared with non-AIBD controls, AIBD patients reported lower SF-36 scores (P < 0.05) and severer OSDI, Schirmer I test, tear break-up time, corneal fluorescein staining, presence of symblepharon and corneal opacity measures (P < 0.05). OSDI, Schirmer I test were correlated with SF-36 composite scores or scores on the SF-36 subscales. Conclusions AIBD patients experience reduced quality of life and more severe ocular surface disorders including dry eye, symblepharon and corneal opacity. Early treatments of dry eye and collaborations among multidisciplinary physicians are necessary in patients with AIBD.

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“…If the autonomic nervous system is affected, it can generate an exacerbated pro-inflammatory response which can be usually encountered in autoimmune diseases [ 96 ]. Several studies have analyzed the impact of autoimmune diseases on quality of life and have concluded that these patients have an affected quality of life, increased stress, depression and anxiety [ 97 , 98 , 99 , 100 , 101 ]. Disease severity can further impact quality of life, as there is a positive correlation with this index [ 102 ].…”

Section: Management Of the Patient With Dg In The Dental Office And N...mentioning

confidence: 99%

Desquamative Gingivitis in the Context of Autoimmune Bullous Dermatoses and Lichen Planus—Challenges in the Diagnosis and Treatment

et al. 2022

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Desquamative gingivitis (DG) is a clinical term that describes erythema, desquamation and erosions of the gingiva, of various etiologies. Although the clinical aspect is not specific for a certain disease, an accurate diagnosis of the underlying disorder is necessary because the disease course, prognosis and treatment vary according to the cause. DG may inflict significant oral discomfort, which is why patients typically present to the dentist for a first consultation, rendering it important for these specialists to be informed about this condition. Our paper aims to review the ethiopatogenesis and diagnostic approach of DG, focusing on the most common underlying disorders (autoimmune bullous dermatoses and lichen planus) and on the management of these patients. Potential etiological agents leading to an inflammatory immune response in the oral mucosa and DG appearance include genetic predisposition, metabolic, neuropsychiatric, infectious factors, medication, dental materials, graft-versus-host reaction and autoimmunity. A thorough anamnesis, a careful clinical examination, paraclinical explorations including histopathological exam and direct immunofluorescence are necessary to formulate an appropriate diagnosis. Proper and prompt management of these patients lead to a better prognosis and improved quality of life, and must include management in the dental office with sanitizing the oral cavity, instructing the patient for rigorous oral hygiene, periodic follow-up for bacterial plaque detection and removal, as well as topical and systemic therapy depending on the underlying disorder, based on treatment algorithms. A multidisciplinary approach for the diagnosis and follow-up of DG in the context of pemphigus vulgaris, bullous pemphigoid, cicatricial pemhigoid or lichen planus is necessary, including consultations with dermatologists, oral medicine specialists and dentists.

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Assessing the risk factors for anxiety, depression and post‐traumatic stress disorder through the International Pemphigus and Pemphigoid Foundation

Cited by 6 publications

References 11 publications

Psychological morbidity in patients with pemphigus and its clinicodemographic risk factor: A comparative study

Psychological morbidity in patients with pemphigus and its clinicodemographic risk factor: A comparative study

Ocular surface disorders affect quality of life in patients with autoimmune blistering skin diseases: a cross-sectional study

Desquamative Gingivitis in the Context of Autoimmune Bullous Dermatoses and Lichen Planus—Challenges in the Diagnosis and Treatment

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