Assessing the Risk of Aortic Aneurysm in Takayasu Arteritis

Rocha, José Aurillo; Espinoza, Luis R.

doi:10.1016/j.amjms.2017.09.014

Cited by 2 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The risk of aneurysm was 4.2-fold higher in patients with disease duration >5 years. Persistent inflammation of the aortic vessel wall is important risk factor for the development and progression of aortic aneurysms in TAK patients 26 . Inflammation in patients with TAK are thought to be mediated by activated monocytes, macrophages, and T-cells that synthetize pro-inflammatory cytokines, including TNF-α and IL-6 27 .…”

Section: Discussionmentioning

confidence: 99%

Takayasu Arteritis with Dyslipidemia Increases Risk of Aneurysm

Pan

Chen

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Low-density lipoprotein cholesterol (LDL-C) has been associated with the occurrence of abdominal aortic aneurysm. However, whether LDL-C elevation associated with aneurysms in large vessel vasculitis is unknown. The aim of this study is to investigate the clinical and laboratory features of Takayasu arteritis (TAK) and explore the risk factors that associated with aneurysm in these patients. This retrospective study compared the clinical manifestations, laboratory parameters, and imaging results of 103 TAK patients with or without aneurysms and analyzed the risk factors of aneurysm formation. 20.4% of TAK patients were found to have aneurysms. The LDL-C levels was higher in the aneurysm group than in the non-aneurysm group (2.9 ± 0.9 mmol/l vs. 2.4 ± 0.9 mmol/l, p = 0.032). Elevated serum LDL-C levels increased the risk of aneurysm by 5.8-fold (p = 0.021, odds ratio [OR] = 5.767, 95% confidence interval [CI]: 1.302–25.543), and the cutoff value of level of serum LDL-C was 3.08 mmol/l. The risk of aneurysm was 4.2-fold higher in patients with disease duration >5 years (p = 0.042, OR = 4.237, 95% CI: 1.055–17.023), and 2.9-fold higher when an elevated erythrocyte sedimentation rate was present (p = 0.077, OR = 2.851, 95% CI: 0.891–9.115). In this study, elevated LDL-C levels increased the risk of developing aneurysms in patients with TAK.

show abstract

Section: Discussionmentioning

confidence: 99%

Takayasu Arteritis with Dyslipidemia Increases Risk of Aneurysm

Pan

Chen

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Cardiovascular (CV) involvement in TAK confers poor prognosis and can manifest as accelerated atherosclerosis, aneurysms, aortic dissection, pulmonary hypertension, coronary artery disease, valve abnormalities, and myocarditis [2]. Additionally, individuals with TAK had a high prevalence of metabolic syndrome and a higher Framingham score [3].…”

Section: Introductionmentioning

confidence: 99%

Serum osteoprotegerin and its gene polymorphisms in patients with Takayasu’s arteritis: a bicentric cross-sectional study

Cendon Duran,

de Falco Caparbo,

Santiago

et al. 2024

Adv Rheumatol

View full text Add to dashboard Cite

Introduction Takayasu’s arteritis (TAK) patients are at an elevated risk of metabolic syndrome and cardiovascular diseases (CVD). Currently, there are no well-validated biomarkers to assess this risk in this population. Previous research in different cohorts has linked serum levels of osteoprotegerin (OPG) and its polymorphisms to accelerated atherosclerosis and a marker of poor prognosis in CVD. Thus, we assessed this protein as a potential biomarker of CVD in TAK patients. Objectives To evaluate the serum levels of OPG and its SNPs (single nucleotide polymorphisms) in TAK patients and healthy controls, and to associate these parameters with clinical data. Methods This bicentric cross-sectional study included TAK patients who were compared with healthy individuals (control group). The serum levels of OPG and the frequency of OPG SNPs [1181G > C (rs2073618), 245 A > C (rs3134069), 163T > C (rs3102735), and 209 C > T (rs3134070)] were compared between the both groups and associated with clinical data. Results In total, 101 TAK patients and 93 controls were included in the study. The serum levels of OPG (3.8 ± 1.9 vs. 4.3 ± 1.8pmol/L, respectively; P = 0.059), and its four polymorphisms were comparable between both groups. In an additional analysis of only TAK patients, serum OPG levels and its four genes were not associated with any CVD parameters, except for higher OPG levels among patients without dyslipidemia. Conclusion No significant differences were observed in serum OPG levels or in the genotype frequencies of OPG SNPs between the patient and control groups. Similarly, no correlation was found between laboratory parameters and clinical data on CVD risk in TAK patients.

show abstract

Assessing the Risk of Aortic Aneurysm in Takayasu Arteritis

Cited by 2 publications

References 11 publications

Takayasu Arteritis with Dyslipidemia Increases Risk of Aneurysm

Takayasu Arteritis with Dyslipidemia Increases Risk of Aneurysm

Serum osteoprotegerin and its gene polymorphisms in patients with Takayasu’s arteritis: a bicentric cross-sectional study

Contact Info

Product

Resources

About