Assessing the risk of ovarian malignancy algorithm for the conservative management of women with a pelvic mass

Lokich, Elizabeth; Palisoul, M.; Romano, N; Miller, Michael Craig; Robison, Katina; Stuckey, Ashley; DiSilvestro, Paul; Mathews, Cara; Granai, C.O.; Lambert-Messerlian, Geralyn; Moore, Richard G.

doi:10.1016/j.ygyno.2015.09.010

Cited by 12 publications

(12 citation statements)

References 26 publications

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“…For example, while carcinoma antigen 125 (CA125) alone has not been recommended for screening for ovarian carcinoma [29], Lokich et al could show that the combination of CA125 with HE4, using the Risk of Ovarian Malignancy Algorithm (ROMA), might more accurately define the risk of an epithelial ovarian carcinoma, which would prompt a more aggressive diagnostic workup (e.g., laparoscopy) versus a more conservative management strategy of surveillance in low risk women [30]. Furthermore, the recent data on lung cancer screening in high risk individuals using low resolution computed tomography has shown a mortality benefit on a population basis [31].…”

Section: Role Of Tms In Current Clinical Practicementioning

confidence: 99%

Clinically Meaningful Use of Blood Tumor Markers in Oncology

Holdenrieder

Pagliaro

Morgenstern

et al. 2016

BioMed Research International

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Before the introduction of modern imaging techniques and the recent developments in molecular diagnosis, tumor markers (TMs) were among the few available diagnostic tools for the management of cancer patients. Easily obtained from serum or plasma samples, TMs are minimally invasive and convenient, and the associated costs are low. Single TMs were traditionally used but these have come under scrutiny due to their low sensitivity and specificity when used, for example, in a screening setting. However, recent research has shown superior performance using a combination of multiple TMs as a panel for assessment, or as part of validated algorithms that also incorporate other clinical factors. In addition, newer TMs have been discovered that have an increased sensitivity and specificity profile for defined malignancies. The aim of this review is to provide a concise overview of the appropriate uses of both traditional and newer TMs and their roles in diagnosis, prognosis, and the monitoring of patients in current clinical practice. We also look at the future direction of TMs and their integration with other diagnostic modalities and other emerging serum based biomarkers, such as circulating nucleic acids, to ultimately advance diagnostic performance and improve patient management.

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Section: Role Of Tms In Current Clinical Practicementioning

confidence: 99%

Clinically Meaningful Use of Blood Tumor Markers in Oncology

Holdenrieder

Pagliaro

Morgenstern

et al. 2016

BioMed Research International

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“…Approximately 289,000 women in the United States are diagnosed with a pelvic mass each year [2]. When patients are diagnosed with pelvic masses, the first and most important thing is to determine the origin of the masses and then to evaluate whether they are benign or malignant.…”

Section: Introductionmentioning

confidence: 99%

Combined Application of Ultrasound and CT Increased Diagnostic Value in Female Patients with Pelvic Masses

Zhang

et al. 2016

Computational and Mathematical Methods in Medicine

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Purpose. The current study aimed to evaluate whether combined application of ultrasound and CT had increased Diagnostic Value in Female Patients with Pelvic Masses over either method alone. Patients and Methods. 240 female patients with pelvic masses were detected preoperatively with ultrasound and CT prior to surgery. The sensitivity, specificity, and accuracy of ultrasound, CT, and combined ultrasound/CT application were evaluated, respectively. Results. The sensitivity, specificity, and accuracy of ultrasound were 52.8%, 86.7%, and 68.75%, respectively. The sensitivity, specificity, and accuracy of CT were 80.3%, 90.3%, and 85%, respectively. The sensitivity, specificity, and accuracy of combined application of ultrasound and CT were 89%, 94.7%, and 91.7%. The sensitivity, specificity, and accuracy of combined application of ultrasound and CT were higher than those of either ultrasound or CT. Conclusions. The combined application of ultrasound and CT had higher Diagnostic Value in Female Patients with Pelvic Masses than either method alone.

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“…Their results confirmed that nonsurgical management should be considered for SOC identified with ultrasonography and negative ROMA and CA125 levels. 14 The patients qualified for fine-needle aspiration at our department presented SOC under 80 mm in diameter. Cysts with diameters above 80 mm were qualified for surgery.…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of transvaginal ultrasound-guided aspiration of simple ovarian cysts

Kostrzewa¹,

Zając²,

Wilczyński³

et al. 2019

Adv Clin Exp Med

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Background. The widespread availability of ultrasonography means that transvaginal ultrasonography has become a routine procedure during gynecological examinations, even in asymptomatic patients. Nowadays the imaging technology offered by ultrasonography and tumor biomarkers give us an opportunity to implement transvaginal ultrasound-guided aspiration as a less radical treatment of simple ovarian cysts (SOC). Objectives. The aim of the study was a retrospective evaluation of the diagnostic and therapeutic efficacy of transvaginal ultrasound-guided aspiration of SOC in postmenopausal and premenopausal patients. Material and methods. A total of 84 women, divided into a premenopausal group (38/84) and a postmenopausal group (46/84), underwent transvaginal ultrasound-guided aspiration of small SOC (40-80 mm in diameter). Simple cysts were defined ultrasonographically according to the International Ovarian Tumor Analysis (IOTA) guidelines as cysts with negative risk of ovarian malignancy algorithm (ROMA) scores and CA125 levels. Simple ovarian cyst-related data was obtained from medical documentation (diagnostic tests, medical reproductive and surgical history, and clinical status during SOC aspiration). Follow-up data was collected by means of a telephone interview and medical database. The survey included questions focused on cyst recurrence during the 24-month period following the aspiration of SOC. Results. We had 100% compatibility with ultrasound diagnosis and cytological examination of aspirated fluid. The cumulative rate of cyst recurrence among 84 patients was 20.2% (17/84). There was a higher percentage of cyst recurrence in the premenopausal group: 27% (10/38) vs 15.2% (7/46) in the postmenopausal group, but the difference was not statistically significant (hazard ratio (HR) = 1.89, 95% confidence interval (95% CI) = 0.72-4.97; p = 0. 19). Recurrent cysts were treated with laparoscopic cystectomy, adnexectomy or a second aspiration in accordance with individual indications. Conclusions. Ultrasound-guided aspiration of small (<80 mm) adnexal SOC is a diagnostic and alternative therapeutic procedure, which allows cytological examination and may reduce the need for surgery, which is especially beneficial for women of reproductive age.

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Assessing the risk of ovarian malignancy algorithm for the conservative management of women with a pelvic mass

Cited by 12 publications

References 26 publications

Clinically Meaningful Use of Blood Tumor Markers in Oncology

Clinically Meaningful Use of Blood Tumor Markers in Oncology

Combined Application of Ultrasound and CT Increased Diagnostic Value in Female Patients with Pelvic Masses

Retrospective analysis of transvaginal ultrasound-guided aspiration of simple ovarian cysts

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