Assessing the risk of transplant-related complications and individually tailoring the HSCT procedure in children and adolescents—is it possible?

Faraci, Maura; Dini, Giorgio

doi:10.1038/bmt.2008.292

Cited by 4 publications

(1 citation statement)

References 64 publications

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“…Taken together, factors such as IFI, HC with coherent BK virus detection, and the presence of GvHD have been found to be of relevant importance with regard to the development of surgery‐requiring complications. This also applies to conditioning regimens, preceding HSCT as gold standard and has been described to be associated with early and long‐term morbidity (43). These regimens, including irradiation, suppress the immune system, resulting in elevated susceptibility to infectious diseases, which represents a relevant contribution to the development of complications.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of stem cell transplantation‐related complications in children

Lieber

Hauch

Lang

et al. 2012

Pediatric Transplantation

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HSCT is an established treatment option for some children with life-threatening diseases, but complications remain a major cause of morbidity and mortality. This retrospective data analysis addresses the surgical issues of children with HSCT-related complications. Between 2002 and 2008, HSCT was performed in 240 children for leukemias/lymphomas (n=135), solid tumors (n=59), immunodeficiencies (n=20), lipid storage diseases (n=10), autoimmune diseases (n=9), and others (n=7). HSCT-related complications requiring surgery occurred in 24 cases (10%) and most often in the leukemias/lymphomas group (18/24 cases): HC (cystoscopic irrigation, n=7), pulmonary aspergilloses (resection, n=7), bone necroses (core decompression, n=3), GvHD bowel (colostomy/PEG, n=2), ICH (drainage, n=2), bilateral kidney abscess (nephrectomies/renal transplantation, n=1), aspergillosis of the maxillary sinus (decompression, n=1), and post-traumatic wound healing disorder (meshed skin transplantation, n=1). Survival was 50% in the group with surgery and 62% in the group without (p=0.275). Even though this difference was not statistically significant, surgical intervention should be encouraged in all cases to achieve favorable results.

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Section: Discussionmentioning

confidence: 99%