The 5-points Likert response scale system used. The survey distributed to sixteen directors of hospital pharmacy during mass gathering Hajj-2016. The medications safety officer at Makkah region distributed the questionnaire and made follow up on a daily basis used physical visiting and through the telephone call. Results: The survey distributed to sixteen hospitals, the response rate, was eleven hospitals (68.75%). The total score of all ISMP-self assessment of medication safety was 3.39 +/-0.51 (67.68 %) with CI (3.2-3.6) P< 0.05. The average rating of Patient Education domain at all hospital were 3.75 (63.6 %) while the mean score Quality Processes and risk management domain at all hospital were 3.18 (67.8%). The highest score of both domains was a Drug selection, preparation, and labeling errors identified during routine checking processes reported and collected 4.1 (82%). The lowest score of both domains was the Machine-readable coding used to verify all based solutions and additives 2 (40%). Conclusion: The patient education and quality process and risk management related to medication safety were acceptable at the hospital during mass gathering Hajj period. May be the correction of computerized physician order entry and using of new technology will minimize the patient risk and improve hospital pharmacy management of medication safety during a mass gathering in Makkah, Saudi Arabia.