The conflict between economic development and environmental degradation has significantly impeded urban development. Currently, the Chinese government is actively promoting the comprehensive transformation of new-type urbanization. This study measured the quality of urbanization and its degree of coupling coordination in 16 cities in Anhui Province from 2010 to 2020, utilizing 32 indicators across six dimensions: economic development (ED), infrastructure (INF), population development (PD), social development (SD), environmental protection (EP) and urban–rural integration (URI). Additionally, a novel method of sequential relationship analysis, oriented towards “interaction–change” was introduced to calculate indicator weights, which take the interactive degree among various indices and dependencies between neighboring cities into account. The results indicate that urban development in Anhui Province is imbalanced due to a low degree of resource matching. However, there is a positive trend in the relationship between urbanization quality and economic development. Furthermore, although the coupling coordination degree of urbanization quality in most cities fluctuates at different scales, it is still necessary to narrow and optimize the gap between subsystems. For one thing, the above achievements may provide reference for breaking through the traditional static weighting method from the theoretical level. For another, it can also provide decision-makers with valuable insights to establish an intercity complementary management system, so as to achieve sustainable development across the entire region.