Work-related musculoskeletal disorders have become a leading reason for absence from work and account for a high proportion of work-related injuries. It has become clear that both workplace and non-workplace factors, may cause or exacerbate work-related musculoskeletal disorders. The purpose of this study was to investigate the risk factor of work-related musculoskeletal disorders among health providers. This was a systematic review study that used articles from online database of PubMed, Research Gate, Science Direct, Google Scholar, and EBSCO published from 2011 until 2021. There are several risk factors that can lead to musculoskeletal disorders among nurses, namely female gender, old age, low level of education, physical workload, long work experience, high workload, poor work habits, high level of physical activity, stress, anxiety, high demand for physical work, uncomfortable work position, sleep problems, burnout, marital status, BMI, work unit, long duration of work, frequency of working time, long standing time, lifting weights weight, lack of physical exercise, low number of nurses per shift, and night shifts.