Assessing transfluthrin mortality against Aedes aegypti and Culex quinquefasciatus inside and outside US military tents in a northern Florida environment

McMillan, Benjamin E.; Britch, Seth C.; Golden, Frances V.; Aldridge, Robert L.; Moreno, Bianca J.; Bayer, Barbara E.; Linthicum, Kenneth J.

doi:10.1016/j.crpvbd.2021.100067

Cited by 6 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mosquito Shield™ induced substantial reductions in human landing rates of Culex and Mansonia (26-35%) mosquitoes, vectors of human lariasis, in treated houses compared to the placebo. Reductions in densities of such nuisance mosquitoes have been reported in multiple small-scale trials of trans uthrin spatial repellents [16,25]. Protection from nuisance mosquitoes is usually associated with an increased uptake of malaria vector control interventions.…”

Section: Discussionmentioning

confidence: 99%

Mosquito ShieldTM, a transfluthrin passive emanator, protects against pyrethroid-resistant Anopheles gambiae s.l in central Benin

Fongnikin,

Ahoga,

Ndombidje

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Spatial repellents can provide personal and household protection against biting vector mosquitoes by volatising repellents into the air within a given area. Mosquito ShieldTM is a transfluthrin passive emanator undergoing evaluation for malaria control. Studies evaluating its entomological impact against different local malaria vector populations would help guide its deployment in endemic countries. Methods: We performed a two-arm single-blinded small-scale household randomised entomological trial to assess the impact of Mosquito ShieldTM on the human landing rate of wild pyrethroid-resistant Anopheles gambiae sl vector mosquitoes in houses in the Ganhoua village of the Zakpota District of central Benin. From a total of 30 houses, 15 were randomly allocated to receive Mosquito ShieldTM while the remainder received a placebo product. The trial lasted through the life of the Mosquito ShieldTM product (32 days). Mosquito sampling was performed by human landing catches at baseline and at 6 timepoints post-intervention (days 0-1, 7-8, 14-15, 21-22, 28-29 and 31-32). Collections were performed for 2 days at each sampling time point. WHO cylinder bioassays were conducted during the trial with F1, An gambiae sl mosquitoes that emerged from larvae from the study area to assess the intensity of resistance to pyrethroids in the wild vector population. Findings: The vector population in the study area showed a high intensity of resistance to pyrethroids. Baseline An gambiae sl human landing rates were similar in houses in both study arms before product application (11.53/person/night vs 11.67/person/night, p>0.05). A total of 5736 mosquitoes were collected in the placebo control arm and 3862 in the Mosquito ShieldTM arm post-intervention. Overall An gambiae sl human landing rates post-intervention were significantly lower in houses in the Mosquito ShieldTM arm 18.13/person/night) compared to the houses in the placebo control arm (26.84/person/night, IRR=0.658, p<0.001). Over the lifespan of the product, Mosquito ShieldTM provided a significant protective efficacy of 34.2% (22.1%-44.4%, p<0.001) against wild pyrethroid-resistant An gambiae s.l. vectors compared to the placebo. Human landing rates of other nuisance vector mosquito species (Culex and Mansonia) were also reduced in houses treated with Mosquito ShieldTM compared to the placebo. Conclusion: Mosquito ShieldTM, a transfluthrin passive emanator, provided significant protection against pyrethroid-resistant malaria vectors to households in Benin. The spatial repellent shows potential to reduce malaria transmission by pyrethroid-resistant An gambiae sl vector mosquitoes and cover gaps in malaria control when deployed to complement existing vector control interventions.

show abstract

Section: Discussionmentioning

confidence: 99%

Mosquito ShieldTM, a transfluthrin passive emanator, protects against pyrethroid-resistant Anopheles gambiae s.l in central Benin

Fongnikin,

Ahoga,

Ndombidje

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…[14][15][16] Across several continents, extensive laboratory and field assessments have been conducted with important disease vectors, i.e., Aedes spp., Anopheles spp., Culex spp., Mansonia spp., Triatoma infestans, to evaluate their efficacy. 6,13,[17][18][19] Few investigations on the potential environmental impacts of insecticidal paints exist. 1 However, environmental monitoring data collected from habitats adjacent to pyrethroid applications on impervious surfaces provide some insights to their potential mobility.…”

Section: Introductionmentioning

confidence: 99%

“…These products are designed to repel hematophagous, biting insects that are of public health concern 14–16 . Across several continents, extensive laboratory and field assessments have been conducted with important disease vectors, i.e ., Aedes spp ., Anopheles spp ., Culex spp ., Mansonia spp ., Triatoma infestans , to evaluate their efficacy 6,13,17–19 …”

Section: Introductionmentioning

confidence: 99%

Measured efficacy, bioaccumulation, and leaching of a transfluthrin‐based insecticidal paint: a case study with a nuisance, nonbiting aquatic insect

Cavallaro

Sanders

Hladik

2022

Pest Management Science

View full text Add to dashboard Cite

BACKGROUND: Pest management professionals will require a diverse, adaptive abatement toolbox to combat advanced challenges from disease vector and nuisance insect populations. Designed for post-application longevity, insecticidal paints offer extended residual effects on targeted insect pest populations; a measured understanding of active ingredient bioavailability over time is valuable to fully assess treatment efficacy and potential environmental risks. This study was initiated because a nuisance net-spinning caddisfly, Smicridea fasciatella, is lowering the quality of life for riverfront residents at the type locality. RESULTS:We tested the efficacy and potential mobility of a transfluthrin-based paint (a.i. 0.50%), comparing the impacts of UV exposure and substrate texture over time. Direct UV exposure decreased efficacy (⊎ ± S.E. = 0.008 ± 0.001, P < 0.001) and a coarse texture maintained greater efficacy (⊎ ± S.E. = −3.7 ± 1.3, P = 0.004) over time. Notably, the coarse texture + indirect UV treatment maintained 100% mortality after 240 days. UV exposure and substrate texture did not have a significant impact on leachate concentrations over time, and successive immersion tests indicated a two-phase emission pattern. Bioaccumulation increased with time on the cuticle of dead adult S. fasciatella; after 24 h of direct exposure the concentration of transfluthrin was 25.3 ± 0.9 ng/caddisfly with a maximum concentration of 345 ng/caddisfly after 7 days. CONCLUSION: Our predictions were validated with measured, time-dependent impacts on efficacy, leachability, and bioaccumulation. Because of the mobility of active ingredient in the environment, insecticidal paints merit low-impact protocols to improve public health outcomes and environmental safety.

show abstract

Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from “window” entry

Yavasoglu,

Wood,

Bull

et al. 2024

Journal of Medical Entomology

View full text Add to dashboard Cite

Mosquitoes threaten over half of the world’s population through vectored diseases such as malaria, zika, yellow fever, dengue, and chikungunya. Mosquitoes have a highly developed olfactory system attuned to chemotaxis relating to host-seeking, mating, and oviposition behavior. In this study, we aimed to determine the spatial efficacy of 2 plant-based repellent blends (Blend3 and Blend4 that had previously been found to successfully repel Aedes, Anopheles and Culex mosquitoes in wind tunnel assays) in excluding Aedes aegypti from the window entry. A new cage system was developed for parallel “no-choice” and “choice” olfactometric assays. In the no-choice trial, Blends 3 and 4, as well as commercial products (N, N-diethyl-3-methylbenzamide, p-menthane-3,8-diol [PMD], 3-(N-n-butyl-N-acetyl)-amino-propionic acid ethyl ester, and 2-(2-hydroxyethyl)-1-methylpropylstyrene 1-piperidine carboxylate), were adsorbed into filter papers of different sizes and placed in a window created between 2 attached bug dorms. Then, the number of mosquitoes entering the window was counted through a 6-min period. In choice olfactometric assays, Blends 3, 4, and PMD were adsorbed into filter paper and the number of mosquitoes moving away from Blend 3 and PMD were compared. No-choice assays showed that Blend3 (P < 0.001) and Blend4 (P = 0.0012) were more repellent than the best commercial product PMD. Additionally, while Blend 4 was significantly more repellent than Blend 3 (P = 0.012) in the choice assay, overall, these 2 blends show promise as new repellents for the spatial exclusion of Aedes aegypti from window entry alone or as part of a “push-pull’’ strategy.

show abstract

Assessing transfluthrin mortality against Aedes aegypti and Culex quinquefasciatus inside and outside US military tents in a northern Florida environment

Cited by 6 publications

References 31 publications

Mosquito ShieldTM, a transfluthrin passive emanator, protects against pyrethroid-resistant Anopheles gambiae s.l in central Benin

Mosquito ShieldTM, a transfluthrin passive emanator, protects against pyrethroid-resistant Anopheles gambiae s.l in central Benin

Measured efficacy, bioaccumulation, and leaching of a transfluthrin‐based insecticidal paint: a case study with a nuisance, nonbiting aquatic insect

Novo plant-based mosquito repellent shows promise for exclusion of Aedes mosquitoes from “window” entry

Contact Info

Product

Resources

About