Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT

Strauch, Louise Søborg; Eriksen, Rie Østbjerg; Sandgaard, Michael; Kristensen, Thomas Bjerring; Nielsen, Michael Bachmann; Lauridsen, Carsten Ammitzbøl

doi:10.3390/diagnostics6030028

Cited by 5 publications

(2 citation statements)

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“…To date, CTP based on a single-input model has been investigated for the evaluation of various treatments of lung cancer, including chemotherapy, targeted therapy, radiotherapy and interventional therapy. The majority of these studies confirmed CTP as a useful method and found that BF and permeability surface (PS) product decreased after treatment (33)(34)(35)(36)(37). Few studies have been carried out on thermal ablation, and the results have varied.…”

Section: Discussionmentioning

confidence: 99%

CT perfusion imaging can detect residual lung tumor early after radiofrequency ablation: a preliminary animal study on both tumoral and peri-tumoral region assessment

Cheng¹,

Wang²,

Yuan³

et al. 2022

J Thorac Dis

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Background: Radiofrequency ablation (RFA) is a minimally invasive procedure to treat lung cancer.Timely evaluation on residual lung tumor after RFA is crucial to the prognosis, hence, our objective is to assess CT perfusion (CTP) on detection of residual lung tumor early after RFA. Methods: CTP imaging was performed in 24 lung VX2 tumor models 1 day before and within 1 hour after RFA. CTP maps with dual-input (n=24) and single-input [n=13, with predominant ground glass opacity (GGO) after RFA] models were generated using the maximal slope method. Regions of interest were independently placed on the maximal cross-sectional tumor before and after RFA and on GGO after RFA by two thoracic radiologists. The bronchial flow (BF), pulmonary flow (PF) and perfusion index (PI) were compared between pre-RFA and post-RFA images. The parameters (BF, PF and PI of tumor; PF of GGO) of the complete and incomplete RFA groups were compared based on NADH and TUNEL staining and were correlated with the microvascular density (MVD). Results: The BF and PF decreased after RFA (all P values <0.03). The decrease in BF and PF (ΔBF and ΔPF) in the complete RFA group was higher (P=0.01; 0.02). The areas under the curve (AUC) of ΔBF and ΔPF at 14.85 and 17.25 mL/min/100 mL in determination of tumor with complete ablation were 0.80 and 0.78, respectively. ΔBF was positively correlated with MVD (P=0.046, r=0.468). PF of GGO with incomplete RFA was higher (P=0.001). The AUC of PF ≤29.4 mL/min/100 mL in determination of tumor with complete ablation was 0.99. Conclusions: CTP could detect residual lung tumor early after RFA in a rabbit model, which might provide a clinical solution to early treatment assessment after RFA.

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Section: Discussionmentioning

confidence: 99%

CT perfusion imaging can detect residual lung tumor early after radiofrequency ablation: a preliminary animal study on both tumoral and peri-tumoral region assessment

Cheng¹,

Wang²,

Yuan³

et al. 2022

J Thorac Dis

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“…For patients receiving chemotherapy or radiation, CT scan is an excellent method of monitoring tumour progression and response. 31…”

Section: Discussionmentioning

confidence: 99%

Role of computed tomography scan in diagnosis of retroperitoneal masses

Patel

2020

Int Surg J

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Background: In the vast and ever-expanding field of surgery there are only few subjects which have provoked controversy; curiosity related to correct management of patients suffering from various condition of the abdomen. This becomes very true when the patient has a retroperitoneal mass clinically. The problem of retroperitoneal mass was intriguing, fascinating and certainly most perplexing. The present study was planned with the objective to study the various clinical presentations of retroperitoneal mass, and their radiological findings, and co-relation between these various findings.Methods: This was a prospective, cross-sectional study. The study included 30 patients clinically diagnosed having retroperitoneal mass, attending the department of general surgery.Results: The most common affected age group was of 40-50 years (9, 30.00%). The most frequent presenting symptoms were abdominal lump (28, 93.33%). Pallor was the commonest clinical sign (20, 66.67%). Retroperitoneal lymph node masses were the commonest (12, 40.00%) malignant lesions. Retroperitoneal lymphadenopathy was the most common lesion.Conclusions: The retroperitoneum has long been an area poorly visualised by conventional radiographic techniques and in this respect, computed tomography scan has great advantages over other modalities. Hence the modern surgeon should no longer be considered a ‘shadow-gazer' but an anatomist in-vivo.

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Cancer Staging and Classification

2017

Anticancer Therapeutics

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Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT

Cited by 5 publications

References 50 publications

CT perfusion imaging can detect residual lung tumor early after radiofrequency ablation: a preliminary animal study on both tumoral and peri-tumoral region assessment

CT perfusion imaging can detect residual lung tumor early after radiofrequency ablation: a preliminary animal study on both tumoral and peri-tumoral region assessment

Role of computed tomography scan in diagnosis of retroperitoneal masses

Cancer Staging and Classification

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