Assessing Visual Fields in Patients with Retinitis Pigmentosa Using a Novel Microperimeter with Eye Tracking: The MP-3

Igarashi, Nozomi; Matsuura, Masato; Hashimoto, Yukihiko; Hirasawa, Kazunori; Murata, Hiroshi; Inoue, Tatsuya; Obata, Ryo; Aihara, Makoto; Asaoka, Ryo

doi:10.1371/journal.pone.0166666

Cited by 40 publications

(39 citation statements)

References 20 publications

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“…The fact that our study cohort also had no learning effects in conventional perimetry supports that hypothesis. Recently, Igarashi et al [18] published data investigating test-retest reproducibility of the MP-3 and Humphrey Field Analyzer (Carl Zeiss Meditec AG, Germany) in patients with retinitis pigmentosa (RP) and found a high reproducibility for both devices, but slightly lower ICC values as compared to our study. RP patients are usually not that experienced in visual field testing and in advanced stages of RP visual fields are reduced to a central island of visual field.…”

Section: Discussionsupporting

confidence: 44%

Reproducibility of Microperimeter 3 (MP-3) Microperimetry in Open-Angle Glaucoma Patients

et al. 2019

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KeywordsMicroperimetry · Glaucoma · Microperimeter 3 · Visual field AbstractPurpose: Primary open-angle glaucoma (POAG) is a chronic progressive optic neuropathy, leading to degeneration of retinal ganglion cells and characteristic morphological changes at the optic disc. In advanced stages of the disease, functional tests, such as standard automated perimetry (SAP), are the main diagnostic tools to detect progression. Compared to SAP, microperimetry offers fundus imaging with motion tracking to ensure precise stimulation of certain locations of the retina. Aim of the study was to assess reproducibility of microperimetry compared to SAP in patients with POAG. Methods: This prospective monocenter study included patients suffering from POAG with visual field defects in the central 20° zone. After inclusion into the study, 3 consecutive study visits were scheduled within 1 month, assessing microperimetry and SAP at each visit. Results: From 19 patients recruited, data from 18 patients could be analyzed. No significant difference between study visits could be detected in mean retinal sensitivity in microperimetry and SAP (microperimetry p = 0.401; SAP p = 0.644; Friedman's 2-way analysis of variance). The intraclass-correlation coefficient was 0.981 (95% CI 0.978-0.984) for microperimetry and 0.948 (95% CI 0.941-0.955) for SAP. Absolute agreement between deep scotoma points was found in 81 test locations (79%) in microperimetry and in 35 test locations (20%) in SAP (p = 0.003, chi-square test). Conclusions: Microperimetry and conventional perimetry showed high reproducibility, with slightly better performance of microperimetry. However, the reduced angle of visual field in microperimetry limits its application to central glaucomatous field damage.

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Section: Discussionsupporting

confidence: 44%

Reproducibility of Microperimeter 3 (MP-3) Microperimetry in Open-Angle Glaucoma Patients

et al. 2019

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“…In this manner, we would expect to observe highly reproducible measurements of retinal sensitivity. 10 The microperimetry examination was performed in a dark room. All patients underwent a dark adaptation for at least half an hour until the pupil size reached 4mm or larger.…”

Section: Methodsmentioning

confidence: 99%

“…Controversy focused on the potential injury of ILM-peeling. Major side effects of ILM peeling have been reported as potential mechanical or functional injury to retina [2][3][4][5][6][7][8][9][10]. Previous studies about retinal functional changes that caused by ILM peeling are conflicting: a few authors found no changes after peeling [11,12], others showed decrease of retinal sensitivity [13,14].…”

Section: Introductionmentioning

confidence: 99%

The effect of internal limiting membrane peeling to normal retinal function evaluated by microperimetry-3

Wang

You

et al. 2019

Preprint

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BackgroundTo evaluate the effect of internal limiting membrane (ILM) peeling to the function of retina surrounding macular holes (MH) by microperimetry-3(MP-3). MethodsThis is a prospective, cohort study which included 44 eyes of 44 patients with MHs who were treated by 23-gauge 3-port pars plana vitrectomy and ILM peeling with air tamponade. Color fundus photography, retinal optical coherence tomography and MP-3 were used 1 week before and 1, 4 months after operation. In MP-3 examination, a customized follow-up pattern with 45 spots in the central 8° visual field was used. The spots corresponding to the retina surrounding macular holes were selected for comparison of pre-and post-operative function. Results All eyes had achieved an anatomical success at the last follow-up. BCVA (logMAR) significantly improved both in 1 and 4 months after surgery (1.06±0.40 versus 0.53±0.30 and 0.31±0.24, P<0.01). The mean retinal sensitivity (MRS) (in dB) of the retina surrounding macular hole significantly increased 1 and 4 months after ILM peeling: pre-operative 23.46±3.01 dB versus post-operative 26.25±2.31 dB (u=-4.88, P<0.01) in 1 month and 27.14±2.45 dB (t=-6.29, P<0.01) in 4 months. Patients with increased MRS are significantly younger than patients with deceased MRS (59.72±3.22 years versus 65.60±8.19years, P<0.01). After ILM peeling, the increasing extent of MRS was significantly higher in inferior and nasal retina than that in superior and temporal retina both in 1 and 4 months (P<0.05). ConclusionILM peeling in normal retina will not decrease the retinal function in a short-term after surgery.

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“…The maximum luminance of the MP-3 is 10,000 asb, and the stimulus dynamic range is between 0 and 34 dB. [10][11][12][13][14] Only reliable test results (a false-positive rate of <20% and a false-negative rate of <25%) were used in the analyses, as in the HFV SITA test results set in the present study. A fixation loss is not applicable because the MP-3 has an autotracking system, making it possible to project the stimulus only at predefined retinal positions.…”

Section: Functional Dfr Angle Measurementmentioning

confidence: 99%

“…Clinical application of the MP-3 is increasing as it relates to evaluating glaucoma 12 and other eye diseases, such as retinitis pigmentosa. 13,14 Another issue that should be considered when assessing structure-function correlation is the parameter to be evaluated. Previously, either a disc-fovea (DF) angle or a TR angle, or both, were evaluated.…”

mentioning

confidence: 99%

Discordance of Disc-Fovea Raphe Angles Determined by Optical Coherence Tomography and MP-3 Microperimetry in Eyes With a Glaucomatous Hemifield Defect

Mori

Kurimoto

Kanamori

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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The purpose of this study was to evaluate the concordance of a temporal raphe architecture estimated using optical coherence tomography (OCT) and MP-3 microperimetry. METHODS. We enrolled 25 eyes with either an upper or lower glaucomatous hemifield defect, as detected on the Humphrey visual field 30-2 test. A structural temporal raphe was extrapolated from visible end points of retinal nerve fiber bundles present in a perimetrically normal hemiretina on an en face Spectralis OCT image. A functional temporal raphe was drawn as a line from the fovea to the border of at least a 10-dB difference in sensitivity, at vertically adjacent test points, with at least three consecutive pairs among 25 test points placed at 88 to 188 from the fovea (28 intervals) on the MP-3. An angle determined by the optic disc center, the fovea, and the temporal raphe line (the DFR angle) was calculated. Correlations and agreement of the OCT-and MP-3-derived DFR angles and factors affecting discordance of the two estimates were evaluated. RESULTS. Despite no significant demographic differences, the functional DFR angle (mean 6 SD, 171.88 6 3.58) was significantly larger than that of the structural DFR angle (166.58 6 3.28) in 14 eyes with upper hemifield defects and vice versa in 11 eyes with lower hemifield defects (163.48 6 3.08 vs. 170.58 6 3.28). The mean deviation was significantly associated with the functional and structural DFR angle difference in eyes with only upper hemifield defects. CONCLUSIONS. The structural temporal raphe was more deviated to the perimetrically normal hemiretina side than to the functional temporal raphe, thereby suggesting that a structural change may precede a functional loss.

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Assessing Visual Fields in Patients with Retinitis Pigmentosa Using a Novel Microperimeter with Eye Tracking: The MP-3

Cited by 40 publications

References 20 publications

Reproducibility of Microperimeter 3 (MP-3) Microperimetry in Open-Angle Glaucoma Patients

Reproducibility of Microperimeter 3 (MP-3) Microperimetry in Open-Angle Glaucoma Patients

The effect of internal limiting membrane peeling to normal retinal function evaluated by microperimetry-3

Discordance of Disc-Fovea Raphe Angles Determined by Optical Coherence Tomography and MP-3 Microperimetry in Eyes With a Glaucomatous Hemifield Defect

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