Arid and semiarid wetlands, the core geographical unit of desert oases, significantly benefit and improve the ecological environment. In this study, we systematically compared the spatiotemporal dynamics and driving forces of natural and constructed wetlands in arid and semiarid regions of northern China from 1995 to 2019. For these comparisons, we utilized a land-use transition matrix, partial least-squares–structural equation model (PLS-SEM), and geographically weighted regression (GWR) model. The results showed that (1) the area of wetlands as a whole showed an upward trend, with natural and constructed wetlands increasing by 4.16% and 11.86%, respectively. The increases mainly resulted from conversions of grassland and other lands (shrub, sparse vegetation, and bare land). (2) The direct dominant factors that drove natural wetland changes were soil and terrain, while those that drove constructed wetlands were human disturbances. Human disturbance, by affecting soil, had a higher significant indirect effect on natural wetlands. Heat, by affecting moisture, had the greatest indirect effect on constructed wetlands. (3) The sensitivity of natural and constructed wetlands to the responses of different drivers showed significant spatial heterogeneity. This study explores the interaction and driving mechanisms of human and natural attributes on natural and constructed wetlands and provides a scientific foundation for the restoration and sustainable development of wetlands in arid and semiarid areas.