Assessment and Clinical Relevance of Non-Fasting and Postprandial Triglycerides: An Expert Panel Statement

Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects

“…The detrimental effect of excess NEFA, the so called lipotoxicity, contributes to insulin resistance (Bergman and Ader, 2000) and therefore, the weaker suppression of NEFA by WH-meal may relatively enhance long-term insulin resistance in obese non-diabetic individuals compared with the other meals. The high-fat test meals were based on the recommended method (Kolovou et al, 2011) to study postprandial lipaemia but do obviously not reflect a normal diet. Consequently, there is a need for further insight into mechanisms and pathways to understand the observed disparity, as well as long-term studies on ordinary diets to assess the clinical implications of protein supplementation in obese nondiabetic subjects.…”

Magnitude of the Difference between Fasting and Non-fasting Triglycerides, and Its Dependent Factors Running Title: Fasting and Non-fasting Triglycerides

“…Second, other factors such as disorder of lipid metabolism may be more important than the amount of fat intake in determining the difference between fasting and non-fasting triglycerides. It has been suggested that impaired glucose or fat tolerance plays an important role on the levels of non-fasting triglycerides [11,14].…”

“…Conversely, if a very small or no difference between fasting and non-fasting triglycerides is observed in some people, fasting and non-fasting triglycerides can be used interchangeably to predict CVD risk. Further, existing publications suggest that the magnitude of the difference between fasting and non-fasting triglycerides is dependent not only on dietary fat intake, but also on the participants' age, gender and some lipid metabolic factors that may play a role in fat metabolism [9][10][11]. However, few studies have dissected the potential influence of a profile…”

Mediterranean Diet and Cardiovascular Risk

“…While total cholesterol and LDL cholesterol are directly correlated to the risk, this relationship is reverse with HDL cholesterol. Triglycerides, which were not classically considered when assessing cardiovascular risk, have been recently identified as clear modifiers of cardiovascular risk, even independently of cholesterol, and an enlarged postprandial lipemia (which mainly involves triglyceride and triglyceride rich lipoproteins metabolism) has been identified as one of the major cardiovascular risk factors (Bayturan et al, 2010;Kolovou et al, 2011;Langsted et al, 2011;Lopez-Miranda et al, 2006;Patel et al, 2004;Sarwar et al, 2007;van Wijk et al, 2009;Varbo et al, 2011).…”